Cross-Linked Multilayers of Poly(vinyl amine) as a Single Component and Their Interaction with Proteins

被引：25
作者：
Dragan, Ecaterina S. [1 ]
Bucatariu, Florin [1 ]
机构：
[1] Petru Poni Inst Macromol Chem, Iasi 700487, Romania
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2010年 / 31卷 / 03期
关键词：
atomic force microscopy (AFM); crosslinking; human serum albumin; layer-by layer; weak polyelectrolytes; HUMAN SERUM-ALBUMIN; SITU ATR-FTIR; POLYELECTROLYTE MULTILAYERS; THIN-FILMS; POLY(ACRYLIC ACID); ASSEMBLIES; DEPOSITION; ADSORPTION; PARTICLES; SURFACES;
D O I：
10.1002/marc.200900630
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Novel multilayer thin films that consist solely of cross-linked single component layers are generated by a selective cross-linking of the poly(vinyl amine) (PVAm) layers in [PVAm/poly(acrylic acid) (PAA)](n) thin films constructed either on silica particles or silicon wafers, followed by the removal of PAA. The surface topography of the (PVAm), multilayer thin films, before and after the adsorption of human serum albumin (HSA), has been studied by atomic force microscopy on the freeze-dried films. The decrease of the Ark average roughness of the film after the adsorption of HSA F showed the protein was adsorbed into the (PVAm)(n) film making these films potential reservoirs for proteins.
引用
收藏
页码：317 / 322
页数：6
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