CRISPR-Cas antimicrobials: Challenges and future prospects

被引:85
作者
Pursey, Elizabeth [1 ,2 ]
Sunderhauf, David [1 ,2 ]
Gaze, William H. [2 ]
Westra, Edze R. [1 ]
van Houte, Stineke [1 ]
机构
[1] Univ Exeter, Environm & Sustainabil Inst, Ctr Ecol & Conservat, Biosci, Penryn, Cornwall, England
[2] Univ Exeter, Med Sch, European Ctr Environm & Human Hlth, Knowledge Spa,Royal Cornwall Hosp, Truro, Cornwall, England
基金
英国惠康基金; 英国生物技术与生命科学研究理事会; 英国自然环境研究理事会; 欧洲研究理事会; 欧盟地平线“2020”; 英国医学研究理事会;
关键词
SEQUENCE-SPECIFIC ANTIMICROBIALS; GENE DRIVE; RESISTANCE; EVOLUTION; MECHANISMS; NUCLEASES; BACTERIA; SYSTEMS;
D O I
10.1371/journal.ppat.1006990
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
[No abstract available]
引用
收藏
页数:8
相关论文
共 35 条
[1]   Rules of the road for insect gene drive research and testing [J].
Adelman, Zach ;
Akbari, Omar ;
Bauer, John ;
Bier, Ethan ;
Bloss, Cinnamon ;
Carter, Sarah R. ;
Callender, Craig ;
Denis, Adriana Costero-Saint ;
Cowhey, Peter ;
Dass, Brinda ;
Delborne, Jason ;
Devereaux, Mary ;
Ellsworth, Peter ;
Friedman, Robert M. ;
Gantz, Valentino ;
Gibson, Clark ;
Hay, Bruce A. ;
Hoddle, Mark ;
James, Anthony A. ;
James, Stephanie ;
Jorgenson, Lyric ;
Kalichman, Michael ;
Marshall, John ;
McGinnis, William ;
Newman, Jack ;
Pearson, Alan ;
Quemada, Hector ;
Rudenko, Larisa ;
Shelton, Anthony ;
Vinetz, Joseph M. ;
Weisman, Jennifer ;
Wong, Brenda ;
Wozniak, Chris .
NATURE BIOTECHNOLOGY, 2017, 35 (08) :716-718
[2]   To the G20: incentivising antibacterial research and development [J].
Ardal, Christine ;
Baraldi, Enrico ;
Ciabuschi, Francesco ;
Outterson, Kevin ;
Rex, John H. ;
Piddock, Laura J. V. ;
Findlay, David .
LANCET INFECTIOUS DISEASES, 2017, 17 (08) :799-801
[3]   A CRISPR design for next-generation antimicrobials [J].
Beisel, Chase L. ;
Gomaa, Ahmed A. ;
Barrangou, Rodolphe .
GENOME BIOLOGY, 2014, 15 (11)
[4]   Using CRISPR-Cas systems as antimicrobials [J].
Bikard, David ;
Barrangou, Rodolphe .
CURRENT OPINION IN MICROBIOLOGY, 2017, 37 :155-160
[5]   Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials [J].
Bikard, David ;
Euler, Chad W. ;
Jiang, Wenyan ;
Nussenzweig, Philip M. ;
Goldberg, Gregory W. ;
Duportet, Xavier ;
Fischetti, Vincent A. ;
Marraffini, Luciano A. .
NATURE BIOTECHNOLOGY, 2014, 32 (11) :1146-1150
[6]   CRISPR Interference Can Prevent Natural Transformation and Virulence Acquisition during In Vivo Bacterial Infection [J].
Bikard, David ;
Hatoum-Aslan, Asma ;
Mucida, Daniel ;
Marraffini, Luciano A. .
CELL HOST & MICROBE, 2012, 12 (02) :177-186
[7]   The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs [J].
Borges, Adair L. ;
Davidson, Alan R. ;
Bondy-Denomy, Joseph .
ANNUAL REVIEW OF VIROLOGY, VOL 4, 2017, 4 :37-59
[8]  
Carter SR, 2016, POLICY REGULATORY IS, P1
[9]   Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases [J].
Citorik, Robert J. ;
Mimee, Mark ;
Lu, Timothy K. .
NATURE BIOTECHNOLOGY, 2014, 32 (11) :1141-1145
[10]   Adaptive plasmid evolution results in host-range expansion of a broad-host-range plasmid [J].
De Gelder, Leen ;
Williams, Julia J. ;
Ponciano, Jose M. ;
Sota, Masahiro ;
Top, Eva M. .
GENETICS, 2008, 178 (04) :2179-2190