The gut microbiome in pancreatogenic diabetes differs from that of Type 1 and Type 2 diabetes

被引：24

作者：

Talukdar, Rupjyoti ^{[1
,2
,3
]}

Sarkar, Priyanka ^{[1
,2
]}

Jakkampudi, Aparna ^{[1
,2
]}

Sarkar, Subhaleena ^{[1
,2
]}

Aslam, Mohsin ^{[4
]}

Jandhyala, Manasa ^{[1
,2
]}

Deepika, G. ^{[5
]}

Unnisa, Misbah ^{[3
]}

Reddy, D. Nageshwar ^{[3
]}

机构：

[1] Asian Inst Gastroenterol, Pancreas Res Grp, Wellcome DBT India Alliance Labs, Inst Basic & Translat Res,Asian Healthcare Fdn, Hyderabad 500032, Telangana, India

[2] Asian Inst Gastroenterol, Div Gut Microbiome Res, Wellcome DBT India Alliance Labs, Inst Basic & Translat Res,Asian Healthcare Fdn, Hyderabad 500032, Telangana, India

[3] Asian Inst Gastroenterol, Dept Med Gastroenterol, Hyderabad, India

[4] Asian Inst Gastroenterol, Dept Endocrinol, Hyderabad, India

[5] Asian Inst Gastroenterol, Dept Biochem, Hyderabad, India

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

关键词：

IDIOPATHIC CHRONIC-PANCREATITIS; CLINICAL PROFILE; ASSOCIATION; INDIA; INFLAMMATION; MELLITUS; DISEASE; DIET;

D O I：

10.1038/s41598-021-90024-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We hypothesized that the gut microbiome in patients with diabetes secondary to chronic pancreatitis (Type 3c) is different from those with Type 1 and Type 2 diabetes. This was a cross-sectional preliminary study that included 8 patients with Type 1, 10 with Type 2, 17 with Type 3c diabetes and 9 healthy controls. Demographic, clinical, biochemical, imaging and treatment data were recorded and sequencing of the V3-V4 region of the bacterial 16SrRNA was done on fecal samples. Bioinformatics and statistical analyses was performed to evaluate the differences in the diversity indices, distance matrices, relative abundances and uniqueness of organisms between the types of diabetes. There was significant difference in the species richness. Beta diversity was significantly different between patients with Type 3c diabetes and the other groups. 31 genera were common to all the three types of diabetes. There was significant differences in the species level taxa between Type 3c diabetes and the other groups. The unique bacterial species signature in Type 3c diabetes compared to Type 1 and Type 2 diabetes included Nesterenkonia sp. AN1, Clostridium magnum, Acinetobacter lwoffii, Clostridium septicum, Porphyromonas somerae, Terrabacter tumescens, and Synechococus sp.

引用

页数：12

共 52 条

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