A mammalian homolog of the bacterial monomeric sarcosine oxidases maps to mouse chromosome 11, close to Cryba1

被引：4

作者：

Herbst, R ^{[1
]}

Barton, JL ^{[1
]}

Nicklin, MJH ^{[1
]}

机构：

[1] Univ Sheffield, Royal Hallamshire Hosp, Dept Med & Pharmacol, Sect Mol Med, Sheffield S10 2JF, S Yorkshire, England

来源：

GENOMICS | 1997年 / 46卷 / 03期

关键词：

D O I：

10.1006/geno.1997.5050

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have cloned a cDNA from a mouse gene, Pso (peroxisomal sarcosine oxidase). Pso appears to encode a homolog of the single-subunit (40 kDa) bacterial sarcosine oxidases. The mouse Pso gene product would contain a peroxisomal localization sequence, like that of the recently reported rabbit enzyme. Mouse Pso lies between 20 and 50 kb upstream of the promoter of the Sez6 gene, close to Cryba1 on chromosome 11. Pso is expressed very strongly and specifically in liver and kidney. The gene appears to be present widely in eutherian mammals. (C) 1997 Academic Press.

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页码：480 / 482

页数：3

相关论文

共 12 条

[1] GENOMIC SEQUENCING [J].

CHURCH, GM ;

GILBERT, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (07) :1991-1995

[2]

FRANCIS F, 1995, THESIS U LONDON

[3] A CONSERVED TRIPEPTIDE SORTS PROTEINS TO PEROXISOMES [J].

GOULD, SJ ;

KELLER, GA ;

HOSKEN, N ;

WILKINSON, J ;

SUBRAMANI, S .

JOURNAL OF CELL BIOLOGY, 1989, 108 (05) :1657-1664

[4] SEZ-6: Promoter selectivity, genomic structure and localized expression in the brain [J].

Herbst, R ;

Nicklin, MJH .

MOLECULAR BRAIN RESEARCH, 1997, 44 (02) :309-322

[5] CLONING AND EXPRESSION OF THE SARCOSINE OXIDASE GENE FROM BACILLUS SP NS-129 IN ESCHERICHIA-COLI [J].

KOYAMA, Y ;

YAMAMOTOOTAKE, H ;

SUZUKI, M ;

NAKANO, E .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1991, 55 (05) :1259-1263

[6]

MARRA M, 1996, AA242349 EST GEN BAN

[7] THE SELECTIVE ISOLATION OF NOVEL CDNAS ENCODED BY THE REGIONS SURROUNDING THE HUMAN INTERLEUKIN-4 AND INTERLEUKIN-5 GENES [J].

MORGAN, JG ;

DOLGANOV, GM ;

ROBBINS, SE ;

HINTON, LM ;

LOVETT, M .

NUCLEIC ACIDS RESEARCH, 1992, 20 (19) :5173-5179

[8]

*MOUS GEN DAT, 1997, MOUS GEN INF

[9] YAC/P1 CONTIGS DEFINING THE LOCATION OF 56 MICROSATELLITE MARKERS AND SEVERAL GENES ACROSS A 3.4-CM INTERVAL ON MOUSE CHROMOSOME-11 [J].

NEHLS, M ;

LUNO, K ;

SCHORPP, M ;

PFEIFER, D ;

KRAUSE, S ;

MATYSIAKSCHOLZE, U ;

DIERBACH, H ;

BOEHM, T .

MAMMALIAN GENOME, 1995, 6 (05) :321-331

[10] Cloning and functional expression of a mammalian gene for a peroxisomal sarcosine oxidase [J].

Reuber, BE ;

Karl, C ;

Reimann, SA ;

Mihalik, SJ ;

Dodt, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) :6766-6776