Nickel-catalyzed C3-alkylation of indoles with alcohols via a borrowing hydrogen strategy

被引：25

作者：

Hu, Miao ^{[1
]}

Jiang, Yong ^{[1
]}

Sun, Nan ^{[1
]}

Hu, Baoxiang ^{[1
]}

Shen, Zhenlu ^{[1
]}

Hu, Xinquan ^{[1
]}

Jin, Liqun ^{[1
,2
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310032, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

NEW JOURNAL OF CHEMISTRY | 2021年 / 45卷 / 22期

关键词：

C BOND FORMATION; ALPHA-ALKYLATION; UNACTIVATED AMIDES; KETONES; METHYLATION; ESTERS; ARYLACETONITRILES; FUNCTIONALIZATION; COMPLEXES; METHANOL;

D O I：

10.1039/d1nj01581h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient method for the Ni-catalyzed C3-alkylation of indoles using readily available alcohols as the alkylating reagents has been developed. The alkylation was addressed with an air and moisture-stable binuclear nickel complex ligated by tetrahydroquinolin-8-one as the effective pre-catalyst. The newly developed transformation could accommodate a broad substrate scope including primary/secondary benzylic and aliphatic alcohols and substituted indoles. Mechanistic studies suggested that the reaction proceeds through a borrowing hydrogen pathway.

引用

页码：10057 / 10062

页数：6

共 65 条

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