Synthesis of novel ferrocenyl sugars and their antimalarial activities

被引:118
作者
Itoh, T
Shirakami, S
Ishida, N
Yamashita, Y
Yoshida, T
Kim, HS
Wataya, Y
机构
[1] Okayama Univ, Fac Educ, Dept Chem, Okayama 7008530, Japan
[2] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan
关键词
D O I
10.1016/S0960-894X(00)00313-9
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The synthesis of twelve types of novel ferrocenyl sugars and their biological properties towards the malaria parasite (P. falciparum) and mouse cancer cell (FM3A) are described. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1657 / 1659
页数:3
相关论文
共 25 条
  • [1] SYNTHESIS OF SUGAR ORGANOMETALLIC CONJUGATES - FERROCENYL DERIVATIVES
    ADAM, MJ
    HALL, LD
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1979, (19) : 865 - 866
  • [2] SYNTHESIS OF SUGAR-ORGANOMETALLIC CONJUGATES - FERROCENYL MONOSACCHARIDE DERIVATIVES
    ADAM, MJ
    HALL, LD
    [J]. CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1980, 58 (12): : 1188 - 1197
  • [3] Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue
    Biot, C
    Glorian, G
    Maciejewski, LA
    Brocard, JS
    Domarle, O
    Blampain, G
    Millet, P
    Georges, AJ
    Abessolo, H
    Dive, D
    Lebibi, J
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (23) : 3715 - 3718
  • [4] A new ferrocenemethyl-thymidine nucleoside: Synthesis, incorporation into oligonucleotides and optical spectroscopic studies on the resulting single strand, duplex and triplex structures.
    Bucci, E
    De Napoli, L
    Di Fabio, G
    Messere, A
    Montesarchio, D
    Romanelli, A
    Piccialli, G
    Varra, M
    [J]. TETRAHEDRON, 1999, 55 (50) : 14435 - 14450
  • [5] Ellagitannin chemistry. First total synthesis of the 2,3- and 4,6-coupled ellagitannin pedunculagin
    Feldman, KS
    Smith, RS
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (08) : 2606 - 2612
  • [6] Garcia MM, 1997, TETRAHEDRON, V53, P12369
  • [7] CALAMITIC METALLOMESOGENS - METAL-CONTAINING LIQUID-CRYSTALS WITH RODLIKE SHAPES
    HUDSON, SA
    MAITLIS, PM
    [J]. CHEMICAL REVIEWS, 1993, 93 (03) : 861 - 885
  • [8] NEW METHOD OF KINETIC RESOLUTION OF AXIALLY CHIRAL BIARYL COMPOUNDS USING A SUGAR TEMPLATE
    ITOH, T
    CHIKA, JI
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (16) : 4968 - 4969
  • [9] Synthesis of trideca-O-methyl-alpha-pedunculagin. Diastereo-favoritism studies on intramolecular ester-cyclization of axially chiral diphenic acids with carbohydrate core
    Itoh, T
    Chika, J
    Shirakami, S
    Ito, H
    Yoshida, T
    Kubo, Y
    Uenishi, J
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (11) : 3700 - 3705
  • [10] Redox active artificial ferrocenyl ellagitannins. Simple synthesis and their electrochemical properties
    Itoh, T
    Shirakami, S
    Nakao, Y
    Yoshida, T
    [J]. CHEMISTRY LETTERS, 1998, (10) : 979 - 980