Nickel(II) chloride as an efficient and useful catalyst for chemoselective thioacetalization of aldehydes

被引：56

作者：

Khan, AT ^{[1
]}

Mondal, E

Sahu, PR

Islam, S

机构：

[1] Indian Inst Technol, Dept Chem, N Guwahati 781039, Guwahati, India

[2] Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 05期

关键词：

protection; dithioacetals; ethanethiol; thiophenol; 1,2-ethanedithiol; 1,3-propanedithiol; nickel(II) chloride;

D O I：

10.1016/S0040-4039(02)02771-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A wide variety of acyclic and cyclic dithioacetals can be prepared chemoselectively from the corresponding aldehydes by employing a catalytic amount of nickel(II) chloride in dry CH2Cl2-MeOH (5:1) at room temperature in good yields. Some of the major advantages of this procedure are high chemoselectivity, ease of operation, high yields and also compatibility with other protecting groups. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：919 / 922

页数：4

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