Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief

被引：71
作者：
Zhang, Rui [1 ]
Cheng, Liang [1 ]
Dong, Ziliang [1 ]
Hou, Linqian [1 ]
Zhang, Shaohua [1 ]
Meng, Zhouqi [1 ]
Betzer, Oshra [2 ]
Wang, Yihua [1 ]
Popovtzer, Rachela [2 ]
Liu, Zhuang [1 ]
机构：
[1] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Peoples R China
[2] Bar Ilan Univ, Inst Nanotechnol & Adv Mat, IL-52900 Ramat Gan, Israel
来源：
MATERIALS HORIZONS | 2021年 / 8卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Compendex;
D O I：
10.1039/d0mh00193g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe-curcumin CPNs (Fe-Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.
引用
收藏
页码：1314 / 1322
页数：9
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