Parallel synthesis of 3-aminoimidazo[1,2-a]pyridines and pyrazines by a new three-component condensation

被引：348

作者：

Blackburn, C ^{[1
]}

Guan, B ^{[1
]}

Fleming, P ^{[1
]}

Shiosaki, K ^{[1
]}

Tsai, S ^{[1
]}

机构：

[1] Millennium Pharmaceut, Drug Discovery, Cambridge, MA 02139 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(98)00653-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three-component condensation reaction between 2-aminopyridine, an aldehyde and an isonitrile catalyzed by scandium triflate affords derivatives of 3-aminoimidazo[1,2-a]pyridine; aminopyrazine reacts similarly. A library of heterocycles, prepared in high yield by parallel synthesis and purification on an ion-exchange resin, was subjected to further reactions at the amino group. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：3635 / 3638

页数：4

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