Calcium-dependent transcription of cytokine genes in T lymphocytes

被引：43
|
作者：
Savignac, Magali [1 ]
Mellstrom, Britt [1 ]
Naranjo, Jose R. [1 ]
机构：
[1] CSIC, Ctr Nacl Biotecnol, Madrid, Spain
来源：
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2007年 / 454卷 / 04期
关键词：
calcium; cytokines; T lymphocytes; transcription; NFAT; MEF2; DREAM;
D O I：
10.1007/s00424-007-0238-y
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The increase in intracellular calcium ion concentration is a general signaling mechanism used in many biological systems. In T lymphocytes, calcium is essential for activation, differentiation, and effector functions. In this study, we will summarize recent developments of how intracellular calcium concentrations are modified in T cells to affect the activity of three major calcium-dependent transcriptional effectors, i.e., NFAT, MEF2, and DREAM, involved in cytokine gene expression.
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页码：523 / 533
页数：11
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