Calcium-dependent transcription of cytokine genes in T lymphocytes

被引:43
作者
Savignac, Magali [1 ]
Mellstrom, Britt [1 ]
Naranjo, Jose R. [1 ]
机构
[1] CSIC, Ctr Nacl Biotecnol, Madrid, Spain
来源
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2007年 / 454卷 / 04期
关键词
calcium; cytokines; T lymphocytes; transcription; NFAT; MEF2; DREAM;
D O I
10.1007/s00424-007-0238-y
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The increase in intracellular calcium ion concentration is a general signaling mechanism used in many biological systems. In T lymphocytes, calcium is essential for activation, differentiation, and effector functions. In this study, we will summarize recent developments of how intracellular calcium concentrations are modified in T cells to affect the activity of three major calcium-dependent transcriptional effectors, i.e., NFAT, MEF2, and DREAM, involved in cytokine gene expression.
引用
收藏
页码:523 / 533
页数:11
相关论文
共 115 条
  • [61] STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx
    Liou, J
    Kim, ML
    Heo, WD
    Jones, JT
    Myers, JW
    Ferrell, JE
    Meyer, T
    [J]. CURRENT BIOLOGY, 2005, 15 (13) : 1235 - 1241
  • [62] CALCINEURIN IS A COMMON TARGET OF CYCLOPHILIN-CYCLOSPORINE-A AND FKBP-FK506 COMPLEXES
    LIU, J
    FARMER, JD
    LANE, WS
    FRIEDMAN, J
    WEISSMAN, I
    SCHREIBER, SL
    [J]. CELL, 1991, 66 (04) : 807 - 815
  • [63] Molecular analysis of a store-operated and 2-acetyl-sn-glycerol-sensitive non-selective cation channel
    Liu, XB
    Bandyopadhyay, BC
    Singh, BB
    Groschner, K
    Ambudkar, IS
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (22) : 21600 - 21606
  • [64] Loh C, 1996, MOL CELL BIOL, V16, P3945
  • [65] NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun
    López-Rodríguez, C
    Aramburu, J
    Rakeman, AS
    Rao, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (13) : 7214 - 7219
  • [66] Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases
    Lu, JR
    McKinsey, TA
    Zhang, CL
    Olson, EN
    [J]. MOLECULAR CELL, 2000, 6 (02) : 233 - 244
  • [67] Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases
    Lu, JR
    McKinsey, TA
    Nicol, RL
    Olson, EN
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) : 4070 - 4075
  • [68] Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels
    Ma, HT
    Patterson, RL
    van Rossum, DB
    Birnbaumer, L
    Mikoshiba, K
    Gill, DL
    [J]. SCIENCE, 2000, 287 (5458) : 1647 - 1651
  • [69] Partners in transcription:: NFAT and AP-1
    Macián, F
    López-Rodríguez, C
    Rao, A
    [J]. ONCOGENE, 2001, 20 (19) : 2476 - 2489
  • [70] Transcriptional mechanisms underlying lymphocyte tolerance
    Macián, F
    García-Cózar, F
    Im, SH
    Horton, HF
    Byrne, MC
    Rao, A
    [J]. CELL, 2002, 109 (06) : 719 - 731