Dermaseptins, Multifunctional Antimicrobial Peptides: A Review of Their Pharmacology, Effectivity, Mechanism of Action, and Possible Future Directions

被引：40
作者：
Bartels, Emiel Jacob Henri [1 ]
Dekker, Douwe [2 ]
Amiche, Mohamed [3 ]
机构：
[1] Univ Utrecht, Univ Med Ctr, Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, Dutch Poisons Informat Ctr, Utrecht, Netherlands
[3] Univ Paris Est Creteil, Mondor Inst Biomed Res, INSERM, U955,Team 7,Sch Med, Creteil, France
来源：
FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷
关键词：
dermaseptin; Phyllomedusa bicolor; peptide; amphibian; infectious; antimicrobial; tumor; CELL-PENETRATING PEPTIDES; VITRO ANTIVIRAL ACTIVITY; PHYLLOMEDUSA-DISTINCTA; S4; DERIVATIVES; FROG-SKIN; LEAF FROG; ANTIBACTERIAL PROPERTIES; TUMOR-CELLS; MEMBRANE; SEQUENCE;
D O I：
10.3389/fphar.2019.01421
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Dermaseptins are a group of alpha-helical shaped polycationic peptides isolated from the Hylid frogs, with antimicrobial effects against bacteria, parasites, protozoa, viruses in vitro. Besides, anti-tumor effects have been demonstrated. However, few animal experiments and no clinical trials have been conducted thus far. This review summarizes the current knowledge on the pharmacology, ethno pharmacology, effectivity against infectious pathogens and tumors cells and the mechanism of action of the Dermaseptins. Future research should focus on further clarification of the mechanisms of action, the effectivity of Dermaseptins against several cancer cell lines and their applicability in humans.
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页数：11
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