An Optical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H2S Upregulation in Mice

被引：166

作者：

Chen, Zhongyan ^{[1
]}

Mu, Xueling ^{[3
]}

Han, Zhong ^{[1
]}

Yang, Shiping ^{[3
]}

Zhang, Changli ^{[1
]}

Guo, Zijian ^{[1
,2
]}

Bai, Yang ^{[1
]}

He, Weijiang ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, Coordinat Chem Inst, State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China

[2] Nanjing Univ, Chem & Biomed Innovat Ctr, Nanjing 210023, Jiangsu, Peoples R China

[3] Shanghai Normal Univ, Key Lab Resource Chem, Shanghai 200234, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 45期

基金：

中国国家自然科学基金;

关键词：

HYDROGEN-SULFIDE; FLUORESCENCE PROBES; SIGNALING PATHWAYS; CANCER; NANOPROBE; STRATEGY; LEVEL; DYE;

D O I：

10.1021/jacs.9b09181

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tracking signaling H2S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and probe concentration. With complementary advantages of fluorescence and photoacoustic (PA) imaging, optical/PA dual-modality imaging was suggested for in/ex vivo H2S imaging. Therefore, a meso-benzoyloxyltricarboheptamethine cyanine, HS-CyBz, was prepared as the first ratiometric optical/PA dual-modality probe for H2S, profiting from a keto-enol transition sensing mechanism. Tail intravenous injection of this probe leads to probe accumulation in the liver of mice, and the endogenous H2S upregulation triggered by S-adenosyl-l-methionine has been verified by ratiometric optical/PA imaging, suggesting the promising potential of this ratiometric dual-modality imaging.

引用

页码：17973 / 17977

页数：5

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