A regulatory role of circRNA-miRNA-mRNA network in osteoblast differentiation

被引：32
作者：
Mohanapriya, R. [1 ]
Akshaya, R. L. [1 ]
Selvamurugan, N. [1 ]
机构：
[1] SRM Inst Sci & Technol, Coll Engn & Technol, Dept Biotechnol, Kattankulathur 603103, Tamil Nadu, India
来源：
BIOCHIMIE | 2022年 / 193卷
关键词：
ncRNAs; Runx2; Osteoblast; OSTEOGENIC DIFFERENTIATION; CIRCULAR RNAS; STEM-CELLS; EXPRESSION; PATHWAYS; PROMOTES; RUNX2; PHOSPHORYLATION; CLASSIFICATION; ACTIVATOR;
D O I：
10.1016/j.biochi.2021.11.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Osteoblast differentiation is an important process in skeletal development and bone remodelling. Serious bone diseases occur from any delay, defect, or imbalance in osteoblastic differentiation. Non-coding RNAs (ncRNAs) play a regulatory role in controlling the expression of proteins under physiological and pathological conditions via inhibiting mRNA translation or degrading mRNA. Circular RNAs (circRNAs) and microRNAs (miRNAs) are the long and small ncRNAs, respectively, which have been reported to regulate the expression of osteoblast marker genes directly or indirectly. Also, recent studies identified the regulatory mechanisms involving the crosstalk among circRNAs, miRNAs, and mRNAs during osteoblast differentiation. Understanding these regulatory mechanisms behind osteoblastic differentiation would help to diagnose or treat bone and bone-related disorders. Hence, the current review comprehensively discussed the regulatory relationship of circRNAs, miRNAs and mRNAs, and their functional role as circRNA-miRNA-mRNA axis in osteoblast differentiation. (C) 2021 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
引用
收藏
页码：137 / 147
页数：11
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