Biology of ischemic and toxic renal tubular cell injury: role of nitric oxide and the inflammatory response

被引：72
|
作者：
Lieberthal, W [1 ]
机构：
[1] Boston Univ, Med Ctr, Sch Med, Dept Med,Dept Clin Res, Boston, MA 02118 USA
来源：
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 1998年 / 7卷 / 03期
关键词：
D O I：
10.1097/00041552-199805000-00009
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Acute ischemic or toxic injury to the kidney induces alterations in the expression of many genes. Some of these molecular responses have been termed `maladaptive' because they exacerbate the tubular damage induced by the initiating insult. Some maladaptive responses include alterations in the activity of nitric oxide synthases and expression of cytokines and adhesion molecules that mediate an inflammatory response. This review focuses on the role of nitric oxide and inflammation in influencing the course of acute renal failure due to ischemic and toxic tubular injury. (C) 1998 Rapid Science Ltd.
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收藏
页码：289 / 295
页数：7
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