Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosa

被引：38
|
作者：
Gayle, S [1 ]
Burnstock, G [1 ]
机构：
[1] UCL Royal Free & Univ Coll Med Sch, Auton Neurosci Inst, London NW3 2PF, England
来源：
CELL AND TISSUE RESEARCH | 2005年 / 319卷 / 01期
关键词：
ATP; purinoceptor; olfaction; vomeronasal; epithelium; rat (Sprague Dawley);
D O I：
10.1007/s00441-004-0979-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Purinoceptor subtypes were localised to various tissue types present within the nasal cavity of the rat, using immunohistochemical methods. P2X(3) receptor immunoreactivity was localised in the primary olfactory neurones located both in the olfactory epithelium and vomeronasal organs (VNO) and also on subepithelial nerve fibres in the respiratory region. P2X(5) receptor immunoreactivity was found in the squamous, respiratory and olfactory epithelial cells of the rat nasal mucosa. P2X(7) receptor immunoreactivity was also expressed in epithelial cells and colocalised with caspase 9 (an apoptotic marker), suggesting an association with apoptosis and epithelial turnover. P2Y(1) receptor immunoreactivity was found within the respiratory epithelium and submucosal glandular tissue. P2Y(2) receptor immunoreactivity was localised to the mucus-secreting cells within the VNO. The possible functional roles of these receptors are discussed.
引用
收藏
页码：27 / 36
页数：10
相关论文
共 50 条
  • [1] Immunolocalisation of P2X and P2Y nucleotide receptors in the rat nasal mucosa
    Shimona Gayle
    Geoffrey Burnstock
    Cell and Tissue Research, 2005, 319 : 27 - 36
  • [2] Medicinal chemistry of adenosine, P2Y and P2X receptors
    Jacobson, Kenneth A.
    Mueller, Christa E.
    NEUROPHARMACOLOGY, 2016, 104 : 31 - 49
  • [3] Modulation of neurotransmitter release by P2X and P2Y receptors in the rat spinal cord
    Heinrich, Attila
    Kittel, Agnes
    Csoelle, Cecilia
    Vizi, E. Sylvester
    Sperlagh, Beata
    NEUROPHARMACOLOGY, 2008, 54 (02) : 375 - 386
  • [4] Localization of P2X and P2Y receptors in dorsal root ganglia of the cat
    Ruan, HZ
    Birder, LA
    de Groat, WC
    Tai, CF
    Roppolo, J
    Buffington, CA
    Burnstock, G
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2005, 53 (10) : 1273 - 1282
  • [5] P2X and P2Y Receptors-Role in the Pathophysiology of the Nervous System
    Puchalowicz, Kamila
    Tarnowski, Maciej
    Baranowska-Bosiacka, Irena
    Chlubek, Dariusz
    Dziedziejko, Violetta
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (12): : 23672 - 23704
  • [6] The P2Y/P2X divide: How it began
    Kennedy, Charles
    BIOCHEMICAL PHARMACOLOGY, 2021, 187
  • [7] PURINOCEPTORS - ARE THERE FAMILIES OF P2X AND P2Y PURINOCEPTORS
    ABBRACCHIO, MP
    BURNSTOCK, G
    PHARMACOLOGY & THERAPEUTICS, 1994, 64 (03) : 445 - 475
  • [8] Evidence for the presence of P2y and P2x receptors with different functions in mouse stomach
    Mulè, F
    Naccari, D
    Serio, R
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2005, 513 (1-2) : 135 - 140
  • [9] Using antibodies against P2Y and P2X receptors in purinergic signaling research
    Brass, Dovrat
    Grably, Melanie R.
    Bronstein-Sitton, Noemi
    Gohar, Ofra
    Meir, Alon
    PURINERGIC SIGNALLING, 2012, 8 : S61 - S79
  • [10] Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart
    Bogdanov, Y
    Rubino, A
    Burnstock, G
    LIFE SCIENCES, 1998, 62 (08) : 697 - 703
12345