Nutrition and aging skin: sugar and glycation

被引：57

作者：

Danby, F. William ^{[1
]}

机构：

[1] Dartmouth Med Sch, Dept Med, Dermatol Sect, Hanover, NH 03104 USA

来源：

CLINICS IN DERMATOLOGY | 2010年 / 28卷 / 04期

关键词：

END-PRODUCTS; AUTOFLUORESCENCE; AGE; MICROBIOTA; PROSPECTS; STRESS;

D O I：

10.1016/j.clindermatol.2010.03.018

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The effect of sugars on aging skin is governed by the simple act of covalently cross-linking two collagen fibers, which renders both of them incapable of easy repair. Glucose and fructose link the amino acids present in the collagen and elastin that support the dermis, producing advanced glycation end products or "AGEs." This process is accelerated in all body tissues when sugar is elevated and is further stimulated by ultraviolet light in the skin. The effect on vascular, renal, retinal, coronary, and cutaneous tissues is being defined, as are methods of reducing the glycation load through careful diet and use of supplements. (C) 2010 Published by Elsevier Inc.

引用

页码：409 / 411

页数：3

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