Detection of receptor-ligand interactions with an GHz impedance biosensor system

被引：0
|
作者：
Schlecht, U. [1 ]
Gronewold, T. M. A. [1 ]
Malave, A. [1 ]
Tewes, M. [1 ]
Loehndorf, M. [1 ]
机构：
[1] Ctr Adv European Studies & Res, D-53175 Bonn, Germany
来源：
2006 IEEE SENSORS, VOLS 1-3 | 2006年
关键词：
D O I：
暂无
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
Nanogap impedance biosensors with electrode separation of 75 nm have been used for the specific detection of biological interactions. Different model systems, such as thrombin - anti-thrombin antibody, and Rev-peptide - antiRev aptamer are presented. In order to improve the signal-to-noise ratio the use of reference sensors has been explored. The interaction of prostate specific antigen (PSA) to an anti-PSA antibody is shown to demonstrate the detection at concentrations as low as 10 nM.
引用
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页码：255 / +
页数：2
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