Ultrasound measurements of brain structures differ between moderate-late preterm and full-term infants at term equivalent age

被引：7

作者：

Boswinkel, Vivian ^{[1
,2
]}

Sok, Femke I. ^{[1
]}

Kruse-Ruijter, Martine F. ^{[1
]}

Nijholt, Ingrid M. ^{[3
]}

Jansen, Fenna A. R. ^{[4
]}

Haak, Monique C. ^{[4
]}

Boomsma, Martijn F. ^{[3
]}

de Vries, Linda S. ^{[5
]}

Steggerda, Sylke J. ^{[6
]}

van Wezel-Meijler, Gerda ^{[1
]}

机构：

[1] Women & Childrens Hosp, Dept Neonatol, Dokter Heesweg 2, NL-8025 AB Zwolle, Netherlands

[2] Univ Utrecht, Univ Med Ctr Utrecht Brain Ctr, Univ Sweg 100, NL-3584 CG Utrecht, Netherlands

[3] Dept Radiol, Dokter Heesweg 2, NL-8025 AB Zwolle, Netherlands

[4] Leiden Univ, Med Ctr, Div Prenatal Diag & Fetal Med, Dept Obstet, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands

[5] Univ Utrecht, Med Ctr, Wilhelmina Kinderziekenhuis, Dept Neonatol, Lundlaan 6, NL-3584 EA Utrecht, Netherlands

[6] Univ Med Ctr Leiden, Willem Alexander Childrens Hosp, Dept Neonatol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands

来源：

EARLY HUMAN DEVELOPMENT | 2021年 / 160卷

关键词：

Moderate-late preterm infants; Cranial ultrasound; Cerebral development; Brain measurements; Reference values; BORN; GROWTH; PREMATURITY; VENTRICLES; VOLUMES; RISK;

D O I：

10.1016/j.earlhumdev.2021.105424

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Background: Brain growth in moderate preterm (MP; gestational age (GA) 32(+0)-33(+6) weeks) and late preterm infants (LP; GA 34(+0)-36+6 weeks) may be impaired, even in the absence of brain injury. Aims: The aims of this study were to assess brain measurements of MP and LP infants, and to compare these with full-term infants (GA > 37 weeks) using linear cranial ultrasound (cUS) at term equivalent age (TEA). Study design: cUS data from two prospective cohorts were combined. Two investigators performed offline measurements on standard cUS planes. Eleven brain structures were compared between MP, LP and full-term infants using uni-and multivariable linear regression. Results were adjusted for postmenstrual age at cUS and corrected for multiple testing. Results: Brain measurements of 44 MP, 54 LP and 52 full-term infants were determined on cUS scans at TEA. Biparietal diameter and basal ganglia-insula width were smaller in MP (-9.1 mm and -1.7 mm, p < 0.001) and LP infants (-7.0 mm and -1.7 mm, p < 0.001) compared to full-term infants. Corpus callosum - fastigium length was larger in MP (+2.2 mm, p < 0.001) than in full-term infants. No significant differences were found between MP and LP infants. Conclusions: These findings suggest that brain growth in MP and LP infants differs from full-term infants. Whether these differences have clinical implications remains to be investigated.

引用

页数：8

共 40 条

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