The role of adipokines in relation to HIV lipodystrophy

被引:40
作者
Sweeney, Laura L. [1 ]
Brennan, Aoife M. [1 ]
Mantzoros, Christos S. [1 ]
机构
[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA
关键词
adiponectin; immune function; leptin; metabolism; resistin; ACTIVE ANTIRETROVIRAL THERAPY; VIRUS-INFECTED PATIENTS; HUMAN GROWTH-HORMONE; REVERSES INSULIN-RESISTANCE; LEPTIN-REPLACEMENT THERAPY; BLOOD MONONUCLEAR-CELLS; BONE-MINERAL DENSITY; DISEASE RISK-FACTORS; ADIPOSE-TISSUE; PROTEASE INHIBITORS;
D O I
10.1097/QAD.0b013e3280adc91e
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:895 / 904
页数:10
相关论文
共 128 条
[1]   Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy [J].
Addy, CL ;
Gavrila, A ;
Tsiodras, S ;
Brodovicz, K ;
Karchmer, AW ;
Mantzoros, CS .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (02) :627-636
[2]  
Arpadi SM, 2001, J ACQ IMMUN DEF SYND, V27, P30, DOI 10.1097/00126334-200105010-00005
[3]   Circulating resistin levels are not associated with fat redistribution, insulin resistance, or metabolic profile in patients with the highly active antiretroviral therapy-induced metabolic syndrome [J].
Barb, D ;
Wadhwa, SG ;
Kratzsch, J ;
Gavrila, A ;
Chan, JL ;
Williams, CJ ;
Karchmer, AW ;
Mantzoros, CS .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (09) :5324-5328
[4]   Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance [J].
Bastard, JP ;
Caron, M ;
Vidal, H ;
Jan, V ;
Auclair, M ;
Vigouroux, C ;
Luboinski, J ;
Laville, M ;
Malachi, M ;
Girard, PM ;
Rozenbaum, W ;
Levan, P ;
Capeau, J .
LANCET, 2002, 359 (9311) :1026-1031
[5]   The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors [J].
Baumann, H ;
Morella, KK ;
White, DW ;
Dembski, M ;
Bailon, PS ;
Kim, HK ;
Lai, CF ;
Tartaglia, LA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8374-8378
[6]   Longitudinal evaluation and risk factors of lipodystrophy and associated metabolic changes in HIV-infected children [J].
Beregszaszi, M ;
Dollfus, C ;
Levine, M ;
Faye, A ;
Deghmoun, S ;
Bellal, N ;
Houang, M ;
Chevenne, D ;
Hankard, R ;
Bresson, JL ;
Blanche, SP ;
Levy-Marchal, C .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2005, 40 (02) :161-168
[7]   The adipocyte-secreted protein Acrp30 enhances hepatic insulin action [J].
Berg, AH ;
Combs, TP ;
Du, XL ;
Brownlee, M ;
Scherer, PE .
NATURE MEDICINE, 2001, 7 (08) :947-953
[8]   Drug Insight: the role of leptin in human physiology and pathophysiology - emerging clinical applications [J].
Brennan, Aoife M. ;
Mantzoros, Christos S. .
NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM, 2006, 2 (06) :318-327
[9]   Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy [J].
Brinkman, K ;
Smeitink, JA ;
Romijn, JA ;
Reiss, P .
LANCET, 1999, 354 (9184) :1112-1115
[10]   Reduced bone mineral density in human immunodeficiency virus-infected patients and its association with increased central adiposity and postload hyperglycemia [J].
Brown, TT ;
Ruppe, MD ;
Kassner, R ;
Kumar, P ;
Kehoe, T ;
Dobs, AS ;
Timpone, J .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (03) :1200-1206