RNA silencing directed against geminiviruses: Post-transcriptional and epigenetic components

被引:106
作者
Raja, Priya
Wolf, Jamie N.
Bisaro, David M. [1 ]
机构
[1] Ohio State Univ, Dept Mol Genet, Columbus, OH 43210 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2010年 / 1799卷 / 3-4期
基金
美国国家科学基金会;
关键词
Viral chromatin; Methylation; Silencing suppression; AL2; protein; L2; GOLDEN-MOSAIC-VIRUS; LEAF-CURL-VIRUS; H3; LYSINE-9; METHYLATION; COAT PROTEIN PROMOTER; REPLICATION INITIATOR PROTEIN; SHORT INTERFERING RNAS; LOCUS-SPECIFIC CONTROL; AL3; GENE-EXPRESSION; SINGLE-STRANDED-DNA; DICER-LIKE PROTEINS;
D O I
10.1016/j.bbagrm.2010.01.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It is well-established that plants use cytoplasmic, post-transcriptional gene silencing (PTGS) as a defense against RNA viruses and DNA virus transcripts. More recently, it has become clear that small RNA-directed methylation leading to transcriptional gene silencing (TGS) is also used as a defense against DNA virus chromatin. Here we use the DNA-containing geminiviruses as models to discuss what is currently known about both types of antiviral silencing, and viral suppression of PTGS and TGS as a counterdefense. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:337 / 351
页数:15
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