Synthesis of 2,3-disubstituted indoles by a rhodium-catalyzed aromatic amino-Claisen rearrangement of N-propargyl anilines

被引：63
|
作者：
Saito, Akio [1 ]
Kanno, Ayumi [1 ]
Hanzawa, Yuji [1 ]
机构：
[1] Showa Pharmaceut Univ, Lab Organ React Chem, Machida, Tokyo 1948543, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 21期
关键词：
alkynes; cyclization; heterocycles; rearrangement; rhodium;
D O I：
10.1002/anie.200605162
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Give me a ring! A cationic RhI catalyst promotes the formation of fused arenes containing a five-membered ring (see scheme) by an aromatic amino-Claisen rearrangement of N-propargyl aniline derivatives in refluxing hexafluoro-2-propanol (HFIP). cod = 1,5-cyclooctadiene, dppp = 1,3-bis(diphenylphosphanyl)propane, Tf = trifluoromethanesulfonyl. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：3931 / 3933
页数：3
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