Sensitive spectrophotometric method for the determination of indomethacin in capsules

被引：23

作者：

Nagaraja, P ^{[1
]}

Vasantha, RA ^{[1
]}

Yathirajan, HS ^{[1
]}

机构：

[1] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2003年 / 31卷 / 03期

关键词：

indomethacin; p-phenylenediamine dihydrochloride; spectrophotometry; capsules;

D O I：

10.1016/S0731-7085(02)00465-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple, sensitive and selective spectrophotometric method for the determination of indomethacin (INM) either in pure form or in capsules is described. The method is based on the coupling reaction of hydrolyzed INM with diazotized p-phenylenediamine dihydrochloride (PPDD) in sulphuric acid medium to give a red coloured product having the absorption maximum at 510 nm. The product is stable for 20 h. Beer's law is obeyed in the concentration range of 0.2-10 mug/ml. Results of the proposed method compare favourably with those of the official methods and offer the merits of sensitivity and stability. Common excipients used as additives in pharmaceutical preparations do not interfere in the proposed method. (C) 2003 Published by Elsevier Science B.V.

引用

页码：563 / 569

页数：7

共 22 条

[1]

BAGGI T R, 1976, Indian Journal of Pharmacy, V38, P101

[2]

Budavari S., 1996, MERCK INDEX ENCY CHE, V12th, P852

[3]

CHOWDARY K P R, 1987, Indian Drugs, V24, P361

[4] KINETICS OF INDOMETHACIN DEGRADATION .1. PRESENCE OF ALKALI [J].

HAJRATWALA, BR ;

DAWSON, JE .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1977, 66 (01) :27-29

[5]

KAZEMIFARD G, 1973, ARCH PHARM, V306, P664

[6] Sensitive spectrophotometric determination of some dibenzazepine drugs with diazotized P-phenylenediamine dihydrochloride [J].

Nagaraja, P ;

Silwadi, MF ;

Syed, AA .

ANALYTICAL LETTERS, 2000, 33 (14) :2913-2926

[7] Novel methods for the rapid spectrophotometric determination of dapsone [J].

Nagaraja, P ;

Yathirajan, HS ;

Sunitha, KR ;

Vasantha, RA .

ANALYTICAL LETTERS, 2002, 35 (09) :1531-1540

[8]

Nagaraja P, 2002, J AOAC INT, V85, P869

[9] Iminodibenzyl as a novel coupling agent for the spectrophotometric determination of sulfonamide derivatives [J].

Nagaraja, P ;

Sunitha, KR ;

Vasantha, RA ;

Yathirajan, HS .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2002, 53 (02) :187-192

[10] Spectrophotometric determination of folic acid in pharmaceutical preparations by coupling reactions with iminodibenzyl or 3-aminophenol or sodium molybdate-pyrocatechol [J].

Nagaraja, P ;

Vasantha, RA ;

Yathirajan, HS .

ANALYTICAL BIOCHEMISTRY, 2002, 307 (02) :316-321

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