Dual stimuli-responsive nano-vehicles for controlled drug delivery: mesoporous silica nanoparticles end-capped with natural chitosan

被引：67

作者：

Hakeem, Abdul ^{[1
]}

Duan, Ruixue ^{[1
]}

Zahid, Fouzia ^{[1
]}

Dong, Chao ^{[1
]}

Wang, Boya ^{[1
]}

Hong, Fan ^{[1
]}

Ou, Xiaowen ^{[1
]}

Jia, Yongmei ^{[1
]}

Lou, Xiaoding ^{[1
]}

Xia, Fan ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Large Format Battery Mat & Syst, Minist Educ, Wuhan 430074, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 87期

关键词：

IRON-OXIDE NANOPARTICLES; CONTROLLED-RELEASE; PHOTODYNAMIC THERAPY; THERANOSTIC NANOMEDICINE; BIOMEDICAL APPLICATIONS; GOLD NANOPARTICLES; POLYMERIC MICELLES; CANCER-CELLS; NANOSPHERE; SYSTEM;

D O I：

10.1039/c4cc04383a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we report natural chitosan end-capped MCM-41 type MSNPs as novel, dual stimuli, responsive nano-vehicles for controlled anticancer drug delivery. The chitosan nanovalves tightly close the pores of the MSNPs to control premature cargo release under physiological conditions but respond to lysozyme and acidic media to release the trapped cargo.

引用

页码：13268 / 13271

页数：4

共 55 条

[1] Liposomes: From a Clinically Established Drug Delivery System to a Nanoparticle Platform for Theranostic Nanomedicine [J].

Al-Jamal, Wafa' T. ;

Kostarelos, Kostas .

ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :1094-1104

[2] Mechanized Silica Nanoparticles: A New Frontier in Theranostic Nanomedicine [J].

Ambrogio, Michael W. ;

Thomas, Courtney R. ;

Zhao, Yan-Li ;

Zink, Jeffrey I. ;

Stoddartt, J. Fraser .

ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :903-913

[3] Luminescent Silica Nanoparticles: Extending the Frontiers of Brightness [J].

Bonacchi, Sara ;

Genovese, Damiano ;

Juris, Riccardo ;

Montalti, Marco ;

Prodi, Luca ;

Rampazzo, Enrico ;

Zaccheroni, Nelsi .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (18) :4056-4066

[4] Mechanised materials [J].

Boyle, Megan M. ;

Smaldone, Ronald A. ;

Whalley, Adam C. ;

Ambrogio, Michael W. ;

Botros, Youssry Y. ;

Stoddart, J. Fraser .

CHEMICAL SCIENCE, 2011, 2 (02) :204-210

[5] Synthesis of hybrid inorganic-organic mesoporous silica by co-condensation of siloxane and organosiloxane precursors [J].

Burkett, SL ;

Sims, SD ;

Mann, S .

CHEMICAL COMMUNICATIONS, 1996, (11) :1367-1368

[6] Polyvalent Nucleic Acid/Mesoporous Silica Nanoparticle Conjugates: Dual Stimuli-Responsive Vehicles for Intracellular Drug Delivery [J].

Chen, Cuie ;

Geng, Jie ;

Pu, Fang ;

Yang, Xinjian ;

Ren, Jinsong ;

Qu, Xiaogang .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (04) :882-886

[7] Controlled Delivery Systems Using Antibody-Capped Mesoporous Nanocontainers [J].

Climent, Estela ;

Bernardos, Andrea ;

Martinez-Manez, Ramon ;

Maquieira, Angel ;

Dolores Marcos, Maria ;

Pastor-Navarro, Nuria ;

Puchades, Rosa ;

Sancenon, Felix ;

Soto, Juan ;

Amoros, Pedro .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (39) :14075-14080

[8] Mechanised nanoparticles for drug delivery [J].

Coti, Karla K. ;

Belowich, Matthew E. ;

Liong, Monty ;

Ambrogio, Michael W. ;

Lau, Yuen A. ;

Khatib, Hussam A. ;

Zink, Jeffrey I. ;

Khashab, Niveen M. ;

Stoddart, J. Fraser .

NANOSCALE, 2009, 1 (01) :16-39

[9] Dendrimers as drug delivery vehicles: non-covalent interactions of bioactive compounds with dendrimers [J].

Crampton, Hannah L. ;

Simanek, Eric E. .

POLYMER INTERNATIONAL, 2007, 56 (04) :489-496

[10] Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles [J].

Dhar, Shanta ;

Gu, Frank X. ;

Langer, Robert ;

Farokhzad, Omid C. ;

Lippard, Stephen J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (45) :17356-17361

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