miR-217 inhibits triple-negative breast cancer cell growth, migration, and invasion through targeting KLF5

被引：45
作者：
Zhou, Wenhui [1 ,2 ,3 ,4 ,5 ]
Song, Fangfang [4 ,5 ,6 ,7 ]
Wu, Qiuju [4 ,5 ,6 ,7 ]
Liu, Rong [4 ,5 ]
Wang, Lulu [2 ,3 ]
Liu, Cuicui [2 ,3 ]
Peng, You [2 ,3 ]
Mao, Shuqin [8 ]
Feng, Jing [1 ,2 ,3 ]
Chen, Ceshi [4 ,5 ]
机构：
[1] Southern Med Univ, Clin Coll 3, Guangzhou, Guangdong, Peoples R China
[2] Southern Med Univ, Affiliated Fengxian Hosp, Dept Lab Med, Shanghai, Peoples R China
[3] Southern Med Univ, Affiliated Fengxian Hosp, Cent Lab, Shanghai, Peoples R China
[4] Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan Province, Peoples R China
[5] Chinese Acad Sci, Kunming Inst Zool, Kunming, Yunnan Province, Peoples R China
[6] Jinzhou Med Univ, Affiliated Fengxian Hosp, Dept Lab Med, Shanghai, Peoples R China
[7] Jinzhou Med Univ, Affiliated Fengxian Hosp, Cent Lab, Shanghai, Peoples R China
[8] Hubei Univ Med, Affiliated Taihe Hosp, Shiyan, Hubei Province, Peoples R China
来源：
PLOS ONE | 2017年 / 12卷 / 04期
关键词：
PANCREATIC DUCTAL ADENOCARCINOMA; TRANSCRIPTION FACTOR; PROTEASOME DEGRADATION; PROLIFERATION; SURVIVAL; MICRORNA-217; CARCINOMA; EXPRESSION; KINASE;
D O I：
10.1371/journal.pone.0176395
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Triple negative breast cancer (TNBC) is one of the most aggressive breast cancers without effective targeted therapies. Numerous studies have implied that KLF5 plays an important roles in TNBC. How is KLF5 regulated by microRNAs has not been well studied. Here, we demonstrated that miR-217 down-regulates the expression of KLF5 and KLF5's downstream target gene FGF-BP and Cyclin D1 in TNBC cell lines HCC1806 and HCC1937. Consequently, miR-217 suppresses TNBC cell growth, migration, and invasion. MiR-217 suppresses TNBC, at least partially, through down-regulating the KLF5 expression. These results suggest that the miR-217-KLF5 axis might serve as a potential target for treatment of TNBC.
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页数：12
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