Investigation of Circulating miRNA-133, miRNA-26, and miRNA-378 as Candidate Biomarkers for Left Ventricular Hypertrophy

被引：6

作者：

Barut, Zerrin ^{[1
]}

Cabbar, Ayca Turer ^{[2
]}

Yilmaz, Seda Gulec ^{[3
]}

Akdeniz, Fatma Tuba ^{[3
]}

Simsek, Mustafa Aytek ^{[2
]}

Capar, Betul ^{[4
]}

Degertekin, Muzaffer ^{[2
]}

Dalan, Altay Burak ^{[3
]}

Yerebakan, Halit ^{[5
]}

Isbir, Turgay ^{[3
]}

机构：

[1] Antalya Bilim Univ, Fac Dent, Dept Basic Med Sci, Antalya, Turkey

[2] Yeditepe Univ, Fac Med, Dept Cardiol, Istanbul, Turkey

[3] Yeditepe Univ, Fac Med, Dept Med Biol, Inonu Cad 26 Agustos Yerleskesi, TR-34755 Istanbul, Turkey

[4] Yeditepe Univ, Inst Hlth Sci, Dept Mol Med, Istanbul, Turkey

[5] Yeditepe Univ, Fac Med, Dept Cardiovasc Surg, Istanbul, Turkey

来源：

IN VIVO | 2021年 / 35卷 / 03期

关键词：

Left ventricular hypertrophy; circulating miRNA; miRNA-133; miRNA-26; miRNA-378; biomarker; MYOCARDIAL FIBROSIS; MICRORNAS; CARDIOMYOPATHY;

D O I：

10.21873/invivo.12417

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: Left ventricular hypertrophy (LVH) involves increased muscular mass of the left ventricle due to increased cardiomyocyte size and is caused by cardiomyopathies. Several microRNAs (miRNAs) have been implicated in processes that contribute to heart disease. This study aimed to examine miRNA-133, miRNA-26 and miRNA-378 as candidate biomarkers to define prognosis in patients with LVH. Patients and Methods: The study group consisted of 70 patients who were diagnosed with LVH and 16 unaffected individuals who served as the control group. Real-time polymerase chain reaction (RT-PCR) was used to analyze serum miRNA-133, miRNA-26, and miRNA-378 expression levels in LVH patients and the control group. Receiver operating characteristic (ROC) curve analysis was performed to assess the diagnostic capability of miRNA-378. Results: When crossing threshold (CT) values were compared between patient and control samples, we found that there were no statistically significant differences in miRNA-133 and miRNA-26 CT values, while the miRNA-378 expression was significantly increased in LVH patients. ROC analysis demonstrated that the expression levels of miRNA-

引用

页码：1605 / 1610

页数：6

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