First-in-human intracochlear application of human stromal cell-derived extracellular vesicles

被引：58
作者：
Warnecke, Athanasia [1 ]
Prenzler, Nils [1 ]
Harre, Jennifer [1 ]
Koehl, Ulrike [2 ,3 ,4 ,5 ]
Gartner, Lutz [1 ]
Lenarz, Thomas [1 ]
Laner-Plamberger, Sandra [6 ,7 ]
Wietzorrek, Georg [8 ]
Staecker, Hinrich [9 ]
Lassacher, Teresa [10 ,11 ]
Hollerweger, Julia [10 ,11 ]
Gimona, Mario [6 ,7 ,10 ,11 ,12 ]
Rohde, Eva [6 ,7 ,10 ,12 ]
机构：
[1] Hannover Med Sch, Dept Otorhinolaryngol Head & Neck Surg, Carl Neuberg Str 1, D-30625 Hannover, Germany
[2] Inst Cellular Therapeut, Hannover, Germany
[3] Hannover Med Sch, Inst Clin Immunol, Hannover, Germany
[4] Univ Leipzig, Leipzig, Germany
[5] Fraunhofer Inst Cell Therapy & Immunol IZI, Leipzig, Germany
[6] Univ Hosp Salzburger Landeskliniken GesmbH SALK, Dept Transfus Med, Strubergasse 21, A-5020 Salzburg, Austria
[7] Paracelsus Med Univ PMU, Salzburg, Austria
[8] Med Univ Innsbruck, Inst Mol & Cellular Pharmacol, Innsbruck, Austria
[9] Univ Kansas, Sch Med, Dept Otolaryngol Head & Neck Surg, Kansas City, KS USA
[10] Paracelsus Med Univ PMU, Spinal Cord Injury & Tissue Regenerat Ctr Salzbur, GMP Unit, Salzburg, Austria
[11] Paracelsus Med Univ PMU, Res Program Nanovesicular Therapeut, Salzburg, Austria
[12] Res & Transfer Ctr Extracellular Vesicle Theralyt, Salzburg, Austria
来源：
JOURNAL OF EXTRACELLULAR VESICLES | 2021年 / 10卷 / 08期
关键词：
cochlear implantation; EVs from umbilical cord-derived mesenchymal stromal cells (UC-MSC-EV); extracellular vesicles; first-in-human intracochlear EV-therapy; hearing loss; immunomodulation; Meniere's disease; vesicle-enriched secretome fraction; COCHLEAR IMPLANTATION; HEARING PRESERVATION; MICROVESICLES PROTECT; INSERTION; IMPACT;
D O I：
10.1002/jev2.12094
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页数：9
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