New C19-diterpenoid alkaloids from the parent roots of Aconitum carmichaelii

被引：16

作者：

Zong, Xing-Xing ^{[1
]}

Yan, Guanyu ^{[1
]}

Wu, Jian-Lin ^{[1
]}

Leung, Elaine Lai-Han ^{[1
]}

Zhou, Hua ^{[1
]}

Li, Na ^{[1
]}

Liu, Liang ^{[1
]}

机构：

[1] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau Inst Appl Res Med & Hlth, Ave Wai Long, Taipa, Macao, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 16期

关键词：

C-19-diterpenoid alkaloids; 8-Butoxy group; 8-Benzoyloxy group; Aconitum carmichaelii; DITERPENOID ALKALOIDS; LATERAL ROOT;

D O I：

10.1016/j.tetlet.2017.03.033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aconitum carmichaelii is a widely used traditional Chinese medicine and important source of clinical drugs. The parent roots of A. carmichaelii were investigated resulting in the isolation and identification of five new C-19-diterpenoid alkaloids; 14 alpha-benzoyloxy-N-ethyl-15 alpha-hydroxy-1 alpha,6 alpha,8 beta,16 beta,18-pen-tamethoxyaconitane formate (1), 14 alpha-benzoyloxy-8 beta-butoxy-N-ethyl-13 beta,15 alpha-dihydroxy-1 alpha,6 alpha,16 beta, 18-tetramethoxyaconitane formate (2), 14 alpha-benzoyloxy-8 beta-butoxy-N-ethy13 beta,6,15 alpha-dihydroxy1 alpha,6 alpha,16 beta,18-tetramethoxylaconitane (3), 14 alpha-benzoyloxy-8 beta-butoxy-3 alpha,13 beta,15 alpha-trihydroxy-1 alpha,6 alpha, 16 beta,18-tetramethoxyl-N-methylaconitane (4) and 8 beta,14 alpha-dibenzoyloxy-N-ethyl-13 beta,15 alpha-tihydroxy-1 alpha, 6 alpha,16 beta,18-tetramethoxyaconitane (5). (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：1622 / 1626

页数：5

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