共 9 条
- [1] Tyrosine kinase inhibitors.: 17.: Irreversible inhibitors of the epidermal growth factor receptor:: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functionsJOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (07) : 1380 - 1397Smaill, JBRewcastle, GWLoo, JAGreis, KDChan, OHReyner, ELLipka, EShowalter, HDHVincent, PWElliott, WLDenny, WA
- [2] Tyrosine kinase inhibitors.: 15.: 4-(phenylamino)quinazoline and 4-(phenylamino)pyrido[d] pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptorJOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (10) : 1803 - 1815Smaill, JBPalmer, BDRewcastle, GWDenny, WAMcNamara, DJDobrusin, EMBridges, AJZhou, HRShowalter, HDHWinters, RTLeopold, WRFry, DWNelson, JMSlintak, VElliot, WLRoberts, BJVincent, PWPatmore, SJ
- [3] Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor FamilyJOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (17) : 8103 - 8124Smaill, Jeff B.Gonzales, Andrea J.Spicer, Julie A.Lee, HelenReed, Jessica E.Sexton, KarenAlthaus, Irene W.Zhu, TongBlack, Shannon L.Blaser, AdrianDenny, William A.Ellis, Paul A.Fakhoury, StephenHarvey, Patricia J.Hook, KenMcCarthy, Florence O. J.Palmer, Brian D.Rivault, FreddySchlosser, KevinEllis, TeresaThompson, Andrew M.Trachet, ErinWinters, R. ThomasTecle, HaileBridges, Alexander
- [4] Tyrosine kinase inhibitors .12. Synthesis and structure-activity relationships for 6-substituted 4-(phenylamino)pyrimido[5,4-d]pyrimidines designed as inhibitors of the epidermal growth factor receptorJOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (12) : 1820 - 1826Rewcastle, GWBridges, AJFry, DWRubin, JRDenny, WA
- [5] Tyrosine kinase inhibitors .10. Isomeric 4-[(3-bromophenyl)amino]pyrido[d]-pyrimidines are potent ATP-binding site inhibitors of the tyrosine kinase function of the epidermal growth factor receptorJOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (09) : 1823 - 1835Rewcastle, GWPalmer, BDThompson, AMBridges, AJCody, DRZhou, HRFry, DWMcMichael, ADenny, WA
- [6] Tyrosine kinase inhibitors.: 18.: 6-substituted 4-anilinoquinazolines and 4-anilinopyrido [3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptorJOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (03) : 429 - 440Smaill, JBShowalter, HDHZhou, HRBridges, AJMcNamara, DJFry, DWNelson, JMSherwood, VVincent, PWRoberts, BJElliott, WLDenny, WA
- [7] Tyrosine kinase inhibitors.: 16.: 6,5,6-tricyclic benzothieno[3,2-d]pyrimidines and pyrimido[5,4-b]- and -[4,5-b]indoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinaseJOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (26) : 5464 - 5474Showalter, HDHBridges, AJZhou, HRSercel, ADMcMichael, AFry, DW
- [8] Tyrosine kinase inhibitors .13. Structure-activity relationships for soluble 7-substituted 4-[(3-bromophenyl)amino]pyrido[4,3-d]pyrimidines designed as inhibitors of the tyrosine kinase activity of the epidermal growth factor receptorJOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (24) : 3915 - 3925Thompson, AMMurray, DKElliott, WLFry, DWNelson, JAShowalter, HDHRoberts, BJVincent, PWDenny, WA
- [9] Tyrosine kinase inhibitors.: 14.: Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)pyrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity of receptors for the EGF family of growth factorsJOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (05) : 742 - 751Rewcastle, GWMurray, DKElliott, WLFry, DWHoward, CTNelson, JMRoberts, BJVincent, PWShowalter, HDHWinters, RTDenny, WA