Children with frequent infections: A proposal for a stepwise assessment and investigation of the immune system

被引：6
作者：
Cassimos, Dimitrios C. [1 ,2 ]
Liatsis, Manolis [1 ]
Stogiannidou, Anastasia [2 ]
Kanariou, Maria G. [1 ]
机构：
[1] Aghia Sophia Childrens Hosp, Dept Immunol Histocompatibil, Ctr Primary Immunodeficiencies Paediat Immunol, Athens, Greece
[2] Democritus Univ Thrace, Dept Pediat, Alexandroupolis, Greece
来源：
PEDIATRIC ALLERGY AND IMMUNOLOGY | 2010年 / 21卷 / 03期
关键词：
infections; immune system; investigation; algorithm; immunodeficiencies; PRIMARY-IMMUNODEFICIENCY-DISEASES; CHRONIC GRANULOMATOUS-DISEASE; LINKED LYMPHOPROLIFERATIVE DISEASE; STEM-CELL TRANSPLANTATION; FLOW-CYTOMETRIC ANALYSIS; WISKOTT-ALDRICH-SYNDROME; BRUTONS TYROSINE KINASE; RECURRENT INFECTIONS; ANTIBODY-RESPONSE; CLINICAL-FEATURES;
D O I：
10.1111/j.1399-3038.2009.00964.x
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Although many children develop frequent infections, only a few have an underlying immune disorder. Children with dysfunction of the immune system develop frequent infections and/or recurrent, persistent, severe, and rare infections. The aim of this review is to provide to the clinician a valuable tool for recognizing any 'discords' of the 'immune-system symphonic orchestra'. By following a reverse route, it will be possible to brighten up the dark and winding road of immunodeficiencies and identify the exact point of immune dysfunction. This is fundamental and crucial to perceive etiologic management and subsequently achieve the best for these young patients and their families.
引用
收藏
页码：463 / 473
页数：11
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