Children with frequent infections: A proposal for a stepwise assessment and investigation of the immune system

被引：6
作者：
Cassimos, Dimitrios C. [1 ,2 ]
Liatsis, Manolis [1 ]
Stogiannidou, Anastasia [2 ]
Kanariou, Maria G. [1 ]
机构：
[1] Aghia Sophia Childrens Hosp, Dept Immunol Histocompatibil, Ctr Primary Immunodeficiencies Paediat Immunol, Athens, Greece
[2] Democritus Univ Thrace, Dept Pediat, Alexandroupolis, Greece
来源：
PEDIATRIC ALLERGY AND IMMUNOLOGY | 2010年 / 21卷 / 03期
关键词：
infections; immune system; investigation; algorithm; immunodeficiencies; PRIMARY-IMMUNODEFICIENCY-DISEASES; CHRONIC GRANULOMATOUS-DISEASE; LINKED LYMPHOPROLIFERATIVE DISEASE; STEM-CELL TRANSPLANTATION; FLOW-CYTOMETRIC ANALYSIS; WISKOTT-ALDRICH-SYNDROME; BRUTONS TYROSINE KINASE; RECURRENT INFECTIONS; ANTIBODY-RESPONSE; CLINICAL-FEATURES;
D O I：
10.1111/j.1399-3038.2009.00964.x
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Although many children develop frequent infections, only a few have an underlying immune disorder. Children with dysfunction of the immune system develop frequent infections and/or recurrent, persistent, severe, and rare infections. The aim of this review is to provide to the clinician a valuable tool for recognizing any 'discords' of the 'immune-system symphonic orchestra'. By following a reverse route, it will be possible to brighten up the dark and winding road of immunodeficiencies and identify the exact point of immune dysfunction. This is fundamental and crucial to perceive etiologic management and subsequently achieve the best for these young patients and their families.
引用
收藏
页码：463 / 473
页数：11
相关论文
共 83 条
  • [1] AN IMMUNODEFICIENCY CHARACTERIZED BY IMPAIRED ANTIBODY-RESPONSES TO POLYSACCHARIDES
    AMBROSINO, DM
    SIBER, GR
    CHILMONCZYK, BA
    JERNBERG, JB
    FINBERG, RW
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 316 (13) : 790 - 793
  • [2] SELECTIVE DEFECT IN THE ANTIBODY-RESPONSE TO HEMOPHILUS-INFLUENZAE TYPE-B IN CHILDREN WITH RECURRENT INFECTIONS AND NORMAL SERUM IGG SUBCLASS LEVELS
    AMBROSINO, DM
    UMETSU, DT
    SIBER, GR
    HOWIE, G
    GOULARTE, TA
    MICHAELS, R
    MARTIN, P
    SCHUR, PH
    NOYES, J
    SCHIFFMAN, G
    GEHA, RS
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1988, 81 (06) : 1175 - 1179
  • [3] Nonmyeloablative stem cell transplantation for congenital immunodeficiencies
    Amrolia, P
    Gaspar, HB
    Hassan, A
    Webb, D
    Jones, A
    Sturt, N
    Mieli-Vergani, G
    Pagliuca, A
    Mufti, G
    Hadzic, N
    Davies, G
    Veys, P
    [J]. BLOOD, 2000, 96 (04) : 1239 - 1246
  • [4] Primary immunodeficiency disorders: Antibody deficiency
    Ballow, M
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2002, 109 (04) : 581 - 591
  • [5] DiGeorge/velocardiofacial syndrome:: FISH studies of chromosomes 22q11 and 10p14, and clinical reports on the proximal 22q11 deletion
    Bartsch, O
    Nemecková, M
    Kocárek, E
    Wagner, A
    Puchmajerová, A
    Poppe, M
    Ounap, K
    Goetz, P
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART A, 2003, 117A (01): : 1 - 5
  • [6] IgG Fc receptor polymorphisms in human disease: Implications for intravenous immunoglobulin therapy
    Binstadt, BA
    Geha, RS
    Bonilla, FA
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2003, 111 (04) : 697 - 703
  • [7] Practice parameter for the diagnosis and management of primary immunodeficiency
    Bonilla, FA
    Bernstein, IL
    Khan, DA
    Ballas, ZK
    Chinen, J
    Frank, MM
    Kobrynski, LJ
    Levinson, AI
    Mazer, B
    Nelson, RP
    Orange, JS
    Routes, JM
    Shearer, WT
    Sorensen, RU
    [J]. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2005, 94 (05) : S1 - S63
  • [8] Population prevalence of diagnosed primary immunodeficiency diseases in the United States
    Boyle, J. M.
    Buckley, R. H.
    [J]. JOURNAL OF CLINICAL IMMUNOLOGY, 2007, 27 (05) : 497 - 502
  • [9] The clinical syndrome of specific antibody deficiency in children
    Boyle, R. J.
    Le, C.
    Tang, M. L-K.
    [J]. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2006, 146 (03) : 486 - 492
  • [10] Primary immunodeficiency or not? Making the correct diagnosis
    Buckley, RH
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (04) : 756 - 758
123456789