Nanoparticles composed of PLGA and hyperbranched poly (amine-ester) as a drug carrier

被引：12

作者：

Wang, Tiewei ^{[1
,2
]}

Jiang, Ming ^{[1
]}

Wu, Yan ^{[1
]}

机构：

[1] Natl Ctr Nanosci & Technol, Beijing 100080, Peoples R China

[2] China Agr Univ, Beijing 100083, Peoples R China

来源：

JOURNAL OF POLYMER RESEARCH | 2010年 / 17卷 / 03期

基金：

国家高技术研究发展计划(863计划);

关键词：

Hyperbranched poly (amine-ester); PLGA; Nanoparticles; Isoniazid; Drug delivery; PLA NANOPARTICLES; BLOCK-COPOLYMERS; IN-VITRO; RELEASE; LIPOSOMES; MICROPARTICLES; ENCAPSULATION; DENDRIMERS; MICELLES;

D O I：

10.1007/s10965-009-9320-9

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A new hyperbranched poly (amine-ester)-poly (lactide-co-glycolide) (HPAE-co-PLGA) copolymer was synthesized by ring-opening polymerization of D, L-lactide, glycolide and a fourth generation branched poly (amine-ester) (HPAE-OHs4) with Sn(Oct)(2) as catalyst. The chemical structures of copolymers were determined by FT-IR, H-1-NMR (C-13 NMR), TGA and their molecular weights were determined by gel permeation chromatography (GPC). Two methods, double emulsion (DE) and nanoprecipitation (NP), were employed to fabricate the polymeric nanoparticles. Isoniazid (INH) was loaded as a model antitubercular drug. Influence of the preparation conditions on the nanoparticles size, encapsulation efficiency and release profile in vitro was investigated. Their entrapment efficiency (EE) to INH could reach 96% at an available condition. In vitro release behavior of NPs showed a continuous release after a burst release. The results showed that the HPAE-co-PLGA copolymer nanoparticles have a promising potential in hydrophilic drug delivery system.

引用

页码：335 / 345

页数：11

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