ABC Transporters in Drug-Refractory Epilepsy: Limited Clinical Significance of Pharmacogenetics?

被引:27
作者
Cascorbi, I. [1 ]
机构
[1] Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, Kiel, Germany
关键词
MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; POLYMORPHISM; EXPRESSION; GENE; ASSOCIATION;
D O I
10.1038/clpt.2009.237
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:15 / 18
页数:4
相关论文
共 10 条
  • [1] Differences in the transport of the antiepileptic drugs phenytoin, levetiracetarn and carbamazepine by human and mouse P-glycoprotein
    Baltes, Steffen
    Gastens, Alexandra M.
    Fedrowitz, Maren
    Potschka, Heidrun
    Kaever, Volkhard
    Loescher, Wolfgang
    [J]. NEUROPHARMACOLOGY, 2007, 52 (02) : 333 - 346
  • [2] Polymorphism of the MDR1/ABCB1 C3435T drug-transporter and resistance to anticonvulsant drugs: A meta-analysis
    Bournissen, Facundo Garcia
    Moretti, Myla E.
    Juurlink, David N.
    Koren, Gideon
    Walker, Mugabe
    Finkelstein, Yaron
    [J]. EPILEPSIA, 2009, 50 (04) : 898 - 903
  • [3] Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs
    Cascorbi, Ingolf
    [J]. PHARMACOLOGY & THERAPEUTICS, 2006, 112 (02) : 457 - 473
  • [4] Functional polymorphisms of the human multidrug-resistance gene:: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    Hoffmeyer, S
    Burk, O
    von Richter, O
    Arnold, HP
    Brockmöller, J
    Johne, A
    Cascorbi, I
    Gerloff, T
    Roots, I
    Eichelbaum, M
    Brinkmann, U
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) : 3473 - 3478
  • [5] One of the hottest topics in epileptology: ABC proteins. Their inhibition may be the future for patients with intractable seizures
    Hughes, John R.
    [J]. NEUROLOGICAL RESEARCH, 2008, 30 (09) : 920 - 925
  • [6] The clinical impact of pharmacogenetics on the treatment of epilepsy
    Loescher, Wolfgang
    Klotz, Ulrich
    Zimprich, Fritz
    Schmidt, Dieter
    [J]. EPILEPSIA, 2009, 50 (01) : 1 - 23
  • [7] Association of ABCB1 genetic variants 3435C>T and 2677G>T to ABCB1 mRNA and protein expression
    Mosyagin, Igor
    Runge, Uwe
    Schroeder, Henry W.
    Dazert, Eike
    Vogelgesang, Silke
    Siegmund, Werner
    Warzok, Rolf W.
    Cascorbi, Ingolf
    [J]. EPILEPSIA, 2008, 49 (09) : 1555 - 1561
  • [8] Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1
    Siddiqui, A
    Kerb, R
    Weale, ME
    Brinkmann, U
    Smith, A
    Goldstein, DB
    Wood, NW
    Sisodiya, SM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (15) : 1442 - 1448
  • [9] MDR1 GENE-EXPRESSION IN BRAIN OF PATIENTS WITH MEDICALLY INTRACTABLE EPILEPSY
    TISHLER, DM
    WEINBERG, KI
    HINTON, DR
    BARBARO, N
    ANNETT, GM
    RAFFEL, C
    [J]. EPILEPSIA, 1995, 36 (01) : 1 - 6
  • [10] Non-response to antiepileptic pharmacotherapy is associated with the ABCC2-24C>T polymorphism in young and adult patients with epilepsy
    Ufer, Mike
    Mosyagin, Igor
    Muhle, Hiltrud
    Jacobsen, Thies
    Haenisch, Sierk
    Haesler, Robert
    Faltraco, Frank
    Remmler, Cornelia
    von Spiczak, Sarah
    Kroemer, Heyo K.
    Runge, Uwe
    Boor, Rainer
    Stephani, Ulrich
    Cascorbi, Ingolf
    [J]. PHARMACOGENETICS AND GENOMICS, 2009, 19 (05) : 353 - 362