Labeling and Glycosylation of Peptides Using Click Chemistry: A General Approach to 18F-Glycopeptides as Effective Imaging Probes for Positron Emission Tomography

被引：105

作者：

Maschauer, Simone ^{[1
]}

Einsiedel, Juergen ^{[4
]}

Haubner, Roland ^{[4
]}

Hocke, Carsten ^{[1
]}

Ocker, Matthias ^{[2
]}

Huebner, Harald ^{[3
]}

Kuwert, Torsten ^{[1
]}

Gmeiner, Peter ^{[4
]}

Prante, Olaf ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Nukl Med Klin, Lab Mol Bildgebung, D-91054 Erlangen, Germany

[2] Univ Klinikum Erlangen, Erlangen, Germany

[3] Med Univ Innsbruck, Innsbruck, Austria

[4] Univ Erlangen Nurnberg, Emil Fischer Ctr, D-91054 Erlangen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 05期

关键词：

click chemistry; glycosylation; peptides; positron emission tomography; radiopharmaceuticals; CYCLIC PENTAPEPTIDES; PARALLEL SYNTHESIS; RECEPTOR LIGANDS; RGD PEPTIDES; EXPRESSION; PET; F-18-GLYCOSYLATION; F-18; RADIOSYNTHESIS; CYCLOADDITION;

D O I：

10.1002/anie.200904137

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Click for PET: An efficient strategy based on click chemistry has been developed for 18F-labeling alkyne-bearing peptides with concomitant glycosylation. The mild conditions and general applicability of this reliable reaction gives access to a new class of 18F- glycopeptide radiopharmaceuticals with improved biological properties for in vivo imaging studies by positron emission tomography (PET). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：976 / 979

页数：4

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