The Developmental Origins of Health and Disease (DOHaD)

被引:61
作者
Lacagnina, Salvatore [1 ]
机构
[1] Lee Hlth, Lee Mem Hosp, Ft Myers, FL 33901 USA
关键词
epigenetics; DNA modification; heredity; genetic code; LONG-TERM CONSEQUENCES; MATERNAL OBESITY; SEMEN QUALITY; DUTCH FAMINE; MEN; NUTRITION; WEIGHT;
D O I
10.1177/1559827619879694
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
For years many have believed that genetic heritage defined one's destiny, if an individual would grow to be healthy, or if he or she would suffer from chronic illness or cancer. Recent scientific evidence and the field of epigenetics has proven this to be untrue. Certainly, the DNA sequence and the genetic code are fixed; but the field of epigenetics has shown how methylation and other chemical modifications of the genome directly influence the production of proteins that can alter the phenotype of an organism. This article will lay out the supporting research, the details on how the internal and external environments influence genetic function, and will allow the reader to develop an action plan necessary to influence the genetic code, with the goal of then moving the individual toward optimal health. These research details will enable health care professionals in every field of medicine to work with patients on positively influencing the genetic output in order to improve the quality of life and longevity.
引用
收藏
页码:47 / 50
页数:4
相关论文
共 50 条
  • [31] Developmental Origins of Adult Disease
    Langley-Evans, Simon C.
    McMullen, Sarah
    MEDICAL PRINCIPLES AND PRACTICE, 2010, 19 (02) : 87 - 98
  • [32] The developmental origins of adult disease
    Joss-Moore, Lisa A.
    Lane, Robert H.
    CURRENT OPINION IN PEDIATRICS, 2009, 21 (02) : 230 - 234
  • [33] Developmental Origins of Nonalcoholic Fatty Liver Disease (NAFLD)
    Itoh, Hiroaki
    Kanayama, Naohiro
    DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (DOHAD): FROM BIOLOGICAL BASIS TO CLINICAL SIGNIFICANCE, 2018, 1012 : 29 - 39
  • [34] Developmental origins of health and disease: Moving from biological concepts to interventions and policy
    Hanson, Mark A.
    Gluckman, Peter D.
    INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, 2011, 115 : S3 - S5
  • [35] Network Approaches for Charting the Transcriptomic and Epigenetic Landscape of the Developmental Origins of Health and Disease
    Lombardo, Salvo Danilo
    Wangsaputra, Ivan Fernando
    Menche, Jorg
    Stevens, Adam
    GENES, 2022, 13 (05)
  • [36] On 'Mismatch' and 'Metabolic Ghettos:' The Conceptualization of Global Health Differences in Research on the Developmental Origins of Health and Disease
    Penkler, Michael
    Mueller, Ruth
    BERICHTE ZUR WISSENSCHAFTSGESCHICHTE, 2018, 41 (03) : 258 - 278
  • [37] Developmental Origins of Health and Disease: The History of the Barker Hypothesis and Assisted Reproductive Technology
    Carpinello, Olivia J.
    DeCherney, Alan H.
    Hill, Micah J.
    SEMINARS IN REPRODUCTIVE MEDICINE, 2018, 36 (3-4) : 177 - 182
  • [38] Developmental Origins of Health and Disease - from a small body size at birth to epigenetics
    Eriksson, Johan G.
    ANNALS OF MEDICINE, 2016, 48 (06) : 456 - 467
  • [39] Epidemiological evidence for the developmental origins of health and disease: effects of prenatal undernutrition in humans
    Roseboom, Tessa J.
    JOURNAL OF ENDOCRINOLOGY, 2019, 242 (01) : T135 - T144
  • [40] Periconceptional environment and the developmental origins of disease
    Velazquez, Miguel A.
    Fleming, Tom P.
    Watkins, Adam J.
    JOURNAL OF ENDOCRINOLOGY, 2019, 242 (01) : T33 - T49