A convenient synthesis of N-vinyl enamides via the lithiation and ring-opening reaction of 2-phenyl-2-oxazolines

被引：5

作者：

Xu, Yi ^{[1
]}

Liu, Xiao-Yu ^{[1
]}

Wang, Zi-Qi ^{[1
]}

Tang, Liang-Fu ^{[1
]}

机构：

[1] Nankai Univ, Dept Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 18期

基金：

中国国家自然科学基金;

关键词：

Oxazoline; Enamide; Lithiation; Ring-opening reaction; VERSATILE BUILDING-BLOCKS; STEREOSELECTIVE-SYNTHESIS; TERTIARY ENAMIDES; ASYMMETRIC-SYNTHESIS; DERIVATIVES; YNAMIDES; ISOMERIZATION; ALLYLAMIDES; AMIDES; REGIO;

D O I：

10.1016/j.tetlet.2017.03.080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient synthesis of N-vinyl enamides via the lithiation and ring-opening reaction of 2-phenyl-2-oxazolines with lithium diisopropylamide at room temperature has been developed. This method is especially suitable for the synthesis of multifunctional enamides. Good yields have been obtained when the reactions were amplified to gram scale. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：1788 / 1791

页数：4

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