Signal transduction and neurosurvival in experimental models of brain injury

被引：14
作者：
Butler, TL [1 ]
Kassed, CA [1 ]
Pennypacker, KR [1 ]
机构：
[1] Univ S Florida, Coll Med, Dept Pharmacol & Therapeut, Neurosci Program, Tampa, FL 33612 USA
来源：
BRAIN RESEARCH BULLETIN | 2003年 / 59卷 / 05期
关键词：
neuron; NF-kappa B; AP-1; growth factor; animal model; signaling pathways;
D O I：
10.1016/S0361-9230(02)00926-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Brain injury and neurodegenerative disease are linked by their primary pathological consequence-death of neurons. Current approaches for the treatment of neurodegeneration are limited. In this review, we discuss animal models of human brain injury and molecular biological data that have been obtained from their analysis. In particular, signal transduction pathways that are associated with neurosurvival following injury to the brain are presented and discussed. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：339 / 351
页数：13
相关论文
共 209 条
[41]  
CRAIN BJ, 1988, NEUROSCIENCE, V27, P387
[42]   Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage [J].
Culmsee, C ;
Stumm, RK ;
Schäfer, MKH ;
Weihe, E ;
Krieglstein, J .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1999, 379 (01) :33-45
[43]   Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment [J].
Davidson, C ;
Gow, AJ ;
Lee, TH ;
Ellinwood, EH .
BRAIN RESEARCH REVIEWS, 2001, 36 (01) :1-22
[44]   Ras signalling and apoptosis [J].
Downward, J .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1998, 8 (01) :49-54
[45]   Signal transduction - New exchange, new target [J].
Downward, J .
NATURE, 1998, 396 (6710) :416-417
[46]   THE ROLE OF INDUCIBLE TRANSCRIPTION FACTORS IN APOPTOTIC NERVE-CELL DEATH [J].
DRAGUNOW, M ;
PRESTON, K .
BRAIN RESEARCH REVIEWS, 1995, 21 (01) :1-28
[47]   IMMEDIATE-EARLY GENE PROTEIN EXPRESSION IN NEURONS UNDERGOING DELAYED DEATH, BUT NOT NECROSIS, FOLLOWING HYPOXIC-ISCHEMIC INJURY TO THE YOUNG-RAT BRAIN [J].
DRAGUNOW, M ;
BEILHARZ, E ;
SIRIMANNE, E ;
LAWLOR, P ;
WILLIAMS, C ;
BRAVO, R ;
GLUCKMAN, P .
MOLECULAR BRAIN RESEARCH, 1994, 25 (1-2) :19-33
[48]   EXPRESSION OF NERVE GROWTH-FACTOR RECEPTOR MESSENGER-RNA IS DEVELOPMENTALLY REGULATED AND INCREASED AFTER AXOTOMY IN RAT SPINAL-CORD MOTONEURONS [J].
ERNFORS, P ;
HENSCHEN, A ;
OLSON, L ;
PERSSON, H .
NEURON, 1989, 2 (06) :1605-1613
[49]   ALTERED GENE-EXPRESSION IN NEURONS DURING PROGRAMMED CELL-DEATH - IDENTIFICATION OF C-JUN AS NECESSARY FOR NEURONAL APOPTOSIS [J].
ESTUS, S ;
ZAKS, WJ ;
FREEMAN, RS ;
GRUDA, M ;
BRAVO, R ;
JOHNSON, EM .
JOURNAL OF CELL BIOLOGY, 1994, 127 (06) :1717-1727
[50]   Early dramatic recovery during intravenous tissue plasminogen activator infusion - Clinical pattern and outcome in acute middle cerebral artery stroke [J].
Felberg, RA ;
Okon, NJ ;
El-Mitwalli, A ;
Burgin, WS ;
Grotta, JC ;
Alexandrov, AV .
STROKE, 2002, 33 (05) :1301-1307
12345678910