Forecasting Cytokine Storms with New Predictive Biomarkers

被引：8

作者：

Rouce, Rayne H. ^{[1
,2
,3
,4
]}

Heslop, Helen E. ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Houston Methodist Hosp, Ctr Cell & Gene Therapy, Houston, TX 77030 USA

[2] Texas Childrens Hosp, Houston, TX 77030 USA

[3] Baylor Coll Med, Texas Childrens Canc Ctr, Houston, TX 77030 USA

[4] Baylor Coll Med, Hematol Ctr, Houston, TX 77030 USA

来源：

CANCER DISCOVERY | 2016年 / 6卷 / 06期

关键词：

CHIMERIC ANTIGEN RECEPTOR; T-CELLS; LEUKEMIA;

D O I：

10.1158/2159-8290.CD-16-0493

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

T cells genetically modified with CD19 chimeric antigen receptors have produced impressive clinical responses in patients with refractory B-cell malignancies, but therapeutic responses are often accompanied by cytokine release syndrome (CRS), which can cause significant morbidity and mortality. Teachey and colleagues have identified predictive biomarkers for this complication that may allow testing of earlier intervention with agents such as the IL6 receptor blocker tocilizumab to evaluate whether CRS can be ameliorated without jeopardizing clinical responses. (C) 2016 AACR.

引用

页码：579 / 580

页数：2

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