Serum cathepsin S and cystatin C: relationship to subclinical carotid atherosclerosis in rheumatoid arthritis

被引:1
|
作者
Tejera-Segura, B. [1 ]
de Vera-Gonzalez, A. M. [2 ]
Lopez-Mejias, R. [3 ]
Gonzalez-Gay, M. A. [4 ,5 ]
Ferraz-Amaro, I. [1 ]
机构
[1] Hosp Univ Canarias, Div Rheumatol, Tenerife, Spain
[2] Hosp Univ Canarias, Cent Lab Div, Tenerife, Spain
[3] IDIVAL, Div Rheumatol, Epidemiol Genet & Atherosclerosis Res Grp Syst In, Santander, Spain
[4] IDIVAL, Hosp Univ Marques de Valdecilla, Div Rheumatol, Santander, Spain
[5] Univ Witwatersrand, Johannesburg, South Africa
关键词
rheumatoid arthritis; cystatin C; cathepsin S; cardiovascular risk; carotid intima-media thickness; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR RISK STRATIFICATION; DISEASE-ACTIVITY INDEX; ULTRASOUND; EVENTS; PREVALENCE; PREDICTION; SEVERITY; SCORES; MATRIX;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective To assess whether serum cathepsin S and cystatin C, two novel markers of cardiovascular disease risk, are associated with subclinical carotid atherosclerosis in patients with rheumatoid arthritis (RA). Methods Serum cystatin C and cathepsin S levels, carotid intima-media thickness (cIMT) and carotid plaques were assessed in a cross-sectional study involving 178 RA patients. Results An association between disease activity scores with higher levels of cystatin C, but not with cathepsin S, was found. Cystatin C levels were also associated with cIMT in the patient subgroup included in the higher quartile of cIMT (OR 1.31, 95%CI [1.00-1.72], p=0.04) after adjusting for traditional cardiovascular risk factors, age and sex. An association between serum cystatin C levels and carotid plaques was also found in the univariate analysis (OR 1.37, 95%CI [1.06-1.76], p=0.02). However, this significant association was lost after adjusting for traditional cardiovascular risk factors and age. Cathepsin S was not associated with cIMT or carotid plaques. Conclusion High cystatin C serum levels identify a subgroup of RA patients with a high risk of subclinical atherosclerotic disease.
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收藏
页码:230 / 235
页数:6
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