Synthesis, nematocidal activity and docking study of novel chiral 1-(3-chloropyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide derivatives

被引：87
|
作者：
Liu, Xing-Hai [1 ]
Zhao, Wen [1 ,2 ]
Shen, Zhong-Hua [1 ]
Xing, Jia-Hua [2 ]
Yuan, Jing [2 ]
Yang, Guo [1 ]
Xu, Tian-Ming [2 ]
Peng, Wei-Li [2 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China
[2] Zhejiang Res Inst Chem Ind, Zhejiang Base Natl Southern Pesticide Res Ctr, Hangzhou 310023, Zhejiang, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 15期
关键词：
Trifluoromethylpyrazole; Chiral chain; Nematocidal activity; Synthesis; Docking; ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; DIMERIC CRYSTAL-STRUCTURE; ANTIFUNGAL ACTIVITY; 1,2,3-THIADIAZOLE DERIVATIVES; BIOLOGICAL-ACTIVITIES; EFFICIENT SYNTHESIS; DESIGN; MOIETY; 1,3,4-THIADIAZOLE;
D O I：
10.1016/j.bmcl.2016.06.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel chiral fluorinated pyrazole carboxamides derivatives were designed and synthesized. All these title compounds were confirmed by NMR and MS. The primarily nematocidal activity results indicated that some of them exhibited good control efficacy against the tomato root-knot nematode disease caused by Meloidogyne incognita. The docking results indicated that compound 5n interact with amino acid residue Tyr 121, Trp 279 of AchE via hydrogen bond. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3626 / 3628
页数：3
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