Use of the Delphi method to facilitate antithrombotics prescription during pregnancy

被引：28
作者：
Chauleur, Celine [1 ,2 ]
Gris, Jean Christophe [3 ]
Laporte, Sylvie [2 ]
Rancon, Florence [2 ]
Varlet, Marie-Noelle [1 ]
Decousus, Herve [2 ]
Mismetti, Patrick [2 ]
机构：
[1] Univ St Etienne, Gynaecol Obstet Dept, Thrombosis Res Grp EA3065, Univ Hosp, F-42055 St Etienne 2, France
[2] Univ St Etienne, Dept Clin Pharmacol, Thrombosis Res Grp EA3065, Univ Hosp, F-42055 St Etienne 2, France
[3] Univ Nimes Hosp, Ctr Biol Explorat Vessels Thromboses & Haemostasi, Caremeau Grp,Haematol Lab, EA Dynam Cardiovasc Incoherencies 2992, F-30029 Nimes 9, France
来源：
THROMBOSIS RESEARCH | 2010年 / 126卷 / 02期
关键词：
Pregnancy; Venous thromboembolism; Risk score; Guidelines; Risk assessment; RECURRENT VENOUS THROMBOEMBOLISM; MOLECULAR-WEIGHT HEPARINS; RISK-FACTORS; CONSENSUS METHODS; FETAL LOSS; PREVENTION; THROMBOSIS; WOMEN; THROMBOPHILIA; MANAGEMENT;
D O I：
10.1016/j.thromres.2010.01.012
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Introduction: Management of pregnant women at risk for venous thromboembolism (VTE) remains complex. Guidelines do not definitively fix optimal strategies due to limited trial data. Our objective was to build aneasy-to-use tool allowing individualised, risk-adapted prophylaxis. Materials and Methods: A Delphi exercise was conducted to collect 19 French experts' opinions on pregnancy-related VTE. Results: Experts with an active interest in clinical research and care of VTE and placental vascular complications were selected. The risk score was classified by an anonymous computer vote. A scoring system for VTE risk in pregnant women was developed, each score being associated with a specific treatment: graduated elastic compression stockings, aspirin, prophylactic Low Molecular Weight Heparin (LMWH: variable durations), or adjusted-dose of LMWH through pregnancy and postpartum. Conclusions: Our simple consensual scoring system offers an individual estimation of thrombosis risk during pregnancy together with its related therapeutic strategy, in accordance with most of the new international recommendations. The accuracy of our individual risk score-based therapeutic guidance is currently being prospectively evaluated in a multicenter trial (Clinicaltrials.gov registry no: NCT00745212). (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：88 / 92
页数：5
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