A one-pot aza-Wittig based solution and polymer supported route to amines

被引：0

作者：

Hemming, K ^{[1
]}

Bevan, MJ ^{[1
]}

Loukou, C ^{[1
]}

Patel, SD ^{[1
]}

Renaudeau, D ^{[1
]}

机构：

[1] Univ Hertfordshire, Div Chem, Hatfield AL10 9AB, Herts, England

来源：

SYNLETT | 2000年 / 11期

关键词：

polymer supported synthesis; amines; imines; aza-Wittig reaction; iminophosphoranes;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper presents a high yielding one-pot solution phase and polymer supported synthesis of a range of primary and secondary amines starting from azides and aldehydes. The synthesis utilises a tandem process which begins with an aza-Wittig reaction between the aldehyde and an iminophosphorane, followed by reduction, or organometallic 1,2-addition reaction, of the resultant imine. The requisite iminophosphoranes were accessed using the highly efficient Staudinger reaction between the azide starting material and a phosphine. The process was applicable to the solid phase by the use of polymer supported iminophosphoranes and polymer supported cyanoborohydride.

引用

页码：1565 / 1568

页数：4

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