A one-pot aza-Wittig based solution and polymer supported route to amines

被引：0
|
作者：
Hemming, K [1 ]
Bevan, MJ [1 ]
Loukou, C [1 ]
Patel, SD [1 ]
Renaudeau, D [1 ]
机构：
[1] Univ Hertfordshire, Div Chem, Hatfield AL10 9AB, Herts, England
来源：
SYNLETT | 2000年 / 11期
关键词：
polymer supported synthesis; amines; imines; aza-Wittig reaction; iminophosphoranes;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This paper presents a high yielding one-pot solution phase and polymer supported synthesis of a range of primary and secondary amines starting from azides and aldehydes. The synthesis utilises a tandem process which begins with an aza-Wittig reaction between the aldehyde and an iminophosphorane, followed by reduction, or organometallic 1,2-addition reaction, of the resultant imine. The requisite iminophosphoranes were accessed using the highly efficient Staudinger reaction between the azide starting material and a phosphine. The process was applicable to the solid phase by the use of polymer supported iminophosphoranes and polymer supported cyanoborohydride.
引用
收藏
页码：1565 / 1568
页数：4
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