A Case-Control Study of ABCB1, ABCB6, and ABCG1 Polymorphisms and Schizophrenia in a Han Chinese Population

被引：4

作者：

Ma, Gaini ^{[1
,3
,4
]}

Huang, Xiaoye ^{[1
,3
,4
]}

Bi, Yan ^{[1
,3
,4
]}

Xu, Fei ^{[1
,3
,4
]}

Niu, Weibo ^{[1
,3
,4
]}

Ren, Decheng ^{[1
,3
,4
]}

Sun, Qianqian ^{[1
,3
,4
]}

Guo, Zhenming ^{[1
,3
,4
]}

Yuan, Ruixue ^{[1
,3
,4
]}

Yuan, Fan ^{[1
,3
,4
]}

Wu, Xi ^{[1
,3
,4
]}

Yang, Fengping ^{[1
,3
,4
]}

Wang, Lu ^{[1
,3
,4
]}

Li, Weidong ^{[1
,3
,4
]}

He, Lin ^{[1
,3
,4
,5
]}

Yu, Tao ^{[1
,3
,4
]}

Li, Xingwang ^{[1
,3
,4
]}

Liu, Jie ^{[2
,3
,4
]}

He, Guang ^{[1
,3
,4
]}

机构：

[1] Shanghai Jiao Tong Univ, Key Lab Genet Dev & Neuropsychiat Disorders, Bio X Inst, Minist Educ, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Ruijin Hosp, Shanghai Inst Orthopaed & Traumatol, Shanghai 200025, Peoples R China

[3] Shanghai Jiao Tong Univ, Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Brain Sci & Technol Res Ctr, Shanghai, Peoples R China

[5] Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China

来源：

NEUROPSYCHOBIOLOGY | 2019年 / 78卷 / 03期

关键词：

ABCB1; ABCB6; ABCG1; Polymorphisms; Schizophrenia; MAJOR DEPRESSIVE DISORDER; FUNCTIONAL POLYMORPHISM; SUICIDAL-BEHAVIOR; ASSOCIATION; GENE; METAANALYSIS; VARIANTS; OBESITY; C3435T;

D O I：

10.1159/000496295

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Schizophrenia (SCZ) is a complex, heritable, and devastating psychiatric disorder. Mutations in the members of ABC transporters have been associated with psychiatric illnesses. Aims: In this study, we investigated whether 9 SNPs in ABCB1 (rs6946119, rs28401781, rs4148739, and rs3747802), ABCB6 (rs1109866, rs1109867, rs3731885, and rs3755047), and ABCG1 (rs182694) contribute to the risk of SCZ in a Han Chinese population. Methods: We conducted a case-control study in a Han Chinese population, involving 1,034 SCZ patients and 1,034 unrelated healthy controls to genotype 9 SNPs. Results: The analysis demonstrated that rs182694 of ABCG1 was significantly different between SCZ patients and controls as to allele (rs182694: p = 0.0070, chi(2) = 7.27) and genotype frequencies (rs182694: p = 0.0013, chi(2) = 13.35). Conclusions: Our findings support an association between ABCG1 polymorphism and SCZ in a Han Chinese population.

引用

页码：113 / 117

页数：5

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