An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by thiamine hydrochloride in water under ultrasound irradiation

被引：64

作者：

Mandhane, Priyanka G. ^{[1
]}

Joshi, Ratnadeep S. ^{[1
]}

Nagargoje, Deepak R. ^{[1
]}

Gill, Charansingh H. ^{[1
]}

机构：

[1] Dr Babasaheb Ambedkor Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 23期

关键词：

Biginelli reaction; Dihydropyrimidinones (DHPMs); Thiamine hydrochloride; Multi-component reactions; Ultrasonication; ONE-POT SYNTHESIS; IONIC LIQUID; BIGINELLI CONDENSATION; REUSABLE CATALYST; FLUORIDE; PROTOCOL; CHLORIDE; BROMIDE; DIHYDROPYRIMIDINONES; DERIVATIVES;

D O I：

10.1016/j.tetlet.2010.04.037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An environmentally benign aqueous Biginelli protocol for the synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones using thiamine hydrochloride as a catalyst has been achieved. These ultrasound-assisted reactions proceed efficiently in water in the absence of organic solvent. Utilization of ultrasound irradiation, simple reaction conditions, isolation, and purification makes this manipulation very interesting from an economic and environmental perspective. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3138 / 3140

页数：3

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