Colonic adenosquamous carcinoma and mucinous adenocarcinoma with microsatellite instability

被引：0
作者：
Parra-Medina, Rafael [1 ,2 ]
Lopez-Correa, Patricia [1 ]
Gutierrez, Victor [1 ]
Polo, Fernando [1 ]
机构：
[1] Fdn Univ Ciencias Salud, Dept Pathol, Hosp Infantil San Jose, Carrera 52 67A-71, Bogota, Colombia
[2] Fdn Univ Ciencias Salud, Res Inst, Bogota, Colombia
来源：
MALAYSIAN JOURNAL OF PATHOLOGY | 2018年 / 40卷 / 02期
关键词：
Adenosquamous carcinoma; mucinous adenocarcinomas; microsatellite instability; COLORECTAL CARCINOMAS; EXPRESSION; FEATURES; SUBTYPE; CANCER; RECTUM;
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
A 43-year old man presented with two-month history of fatigue, weakness, paleness, rectal bleeding, sweating, and weight loss of 10 kg in the past one month. A complete blood count revealed anaemia. The patient underwent a right hemicolectomy. The microscopic examination revealed an adenosquamous carcinoma associated with a mucinous adenocarcinoma in a patient with microsatellite instability due to loss of MLH1 and PMS2 expression and retention of MSH2 and MSH6 expression in both the squamous and glandular components. We also observed an atypical immunohistochemical phenotype in the adenocarcinoma component showing CK7 expression and reduced CK20 and CDX2 expression.
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收藏
页码：199 / 202
页数：4
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