Signal amplification strategies for DNA-based surface plasmon resonance biosensors

被引:52
作者
Zhou, Chen [1 ]
Zou, Haimin [1 ,2 ]
Sun, Chengjun [1 ,3 ]
Ren, Dongxia [1 ]
Chen, Jing [1 ]
Li, Yongxin [1 ,3 ]
机构
[1] Sichuan Univ, West China Sch Publ Hlth, Chengdu 610041, Sichuan, Peoples R China
[2] Chengdu Ctr Dis Control & Prevent, Chengdu 610047, Sichuan, Peoples R China
[3] Prov Key Lab Food Safety Monitoring & Risk Assess, Chengdu 610041, Sichuan, Peoples R China
关键词
Surface plasmon resonance biosensor; Nanomaterial; Electrically neutral DNA probe; DNA amplification; Redox reactions; Enzyme amplification; ROLLING CIRCLE AMPLIFICATION; HIGHLY SENSITIVE DETECTION; LABEL-FREE; GRAPHENE OXIDE; ULTRASENSITIVE DETECTION; ELECTROCHEMICAL BIOSENSOR; STRUCTURAL-PROPERTIES; GOLD NANOPARTICLES; CHAIN-REACTION; QUANTUM DOTS;
D O I
10.1016/j.bios.2018.06.062
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
DNA has well-defined ability to recognize a wide variety of targets, such as small biological molecules, proteins, inorganic ions and small organic molecules. As molecular recognition elements, DNA can be used to build simple, rapid and sensitive biosensors for detection of these targets. DNA-based SPR sensors are considered to be a real-time and label-free tool. We present a systematical and critical review on DNA-based SPR biosensors and their signal amplification via various strategies, focusing on recent advances in nanomaterials, novel DNA amplifications, redox reactions on surface, enzyme amplifications, as well as promising multiplex amplification strategies.
引用
收藏
页码:678 / 689
页数:12
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