Management of the Platelet Refractory Patient

被引：50

作者：

Forest, Stefanie K. ^{[1
]}

Hod, Eldad A. ^{[2
]}

机构：

[1] Columbia Univ, New York Presbyterian Hosp, Med Ctr, Dept Pathol & Cell Biol, 630 West 168th St,VC 14-239, New York, NY 10032 USA

[2] Columbia Univ, New York Presbyterian Hosp, Med Ctr, Dept Pathol & Cell Biol, 630 W 168th St,P&S 14-434, New York, NY 10032 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2016年 / 30卷 / 03期

关键词：

Platelet; Transfusion; Refractoriness; HLA; HPA; Alloimmunization; INDUCED IMMUNE THROMBOCYTOPENIA; TRANSFUSION REFRACTORINESS; HYPOPROLIFERATIVE THROMBOCYTOPENIA; TRANEXAMIC ACID; DONOR PLATELETS; ALLOIMMUNIZATION; SELECTION; ANTIGENS; LEUKEMIA; ANTIBODY;

D O I：

10.1016/j.hoc.2016.01.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Platelet refractoriness occurs when there is an inadequate response to platelet transfusions, which typically has nonimmune causes, but is also associated with alloantibodies to human leukocyte antigens (HLAs) and/or human platelet antigens. Immune-mediated platelet refractoriness is suggested when a 10-minute to 1-hour corrected count increment of less than 5 x 10(9)/L is observed after 2 sequential transfusions using ABO-identical, freshest available platelets. When these antibodies are identified, one of three strategies should be used for identifying compatible platelet units: HLA matching, crossmatching, and antibody specificity prediction. These strategies seem to offer similar results in terms of posttransfusion platelet increments.

引用

页码：665 / +

页数：14

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