Reduction of circular RNA Foxo3 promotes prostate cancer progression and chemoresistance to docetaxel

被引：139
作者：
Shen, Zhiyuan [1 ]
Zhou, Le [2 ]
Zhang, Chao [3 ]
Xu, Jun [1 ]
机构：
[1] Fudan Univ, Huadong Hosp, Dept Urol, 221 West Yanan Rd, Shanghai 200040, Peoples R China
[2] Jilin Univ, China Japan Union Hosp, Dept Thyroid Surg, Jilin Prov Key Lab Surg Translat Med, Changchun 130033, Jilin, Peoples R China
[3] Southern Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Guangdong Prov Key Lab Single Cell Technol & Appl, Guangzhou, Guangdong, Peoples R China
来源：
CANCER LETTERS | 2020年 / 468卷
关键词：
circFoxo3; Prostate cancer; Chemoresistance; Epithelia-lmesenchymal transition (EMT); ESTROGEN; SCORE;
D O I：
10.1016/j.canlet.2019.10.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Dysregulation of circular RNA Foxo3 (circFoxo3) has been reported to be involved in breast cancer and non-small lung cancer progression. However, little is known about the role of circFoxo3 in prostate cancer, which the present study seeks to investigate. CircFoxo3 expression was analyzed in 22 low-grade prostate cancer samples, 24 high-graded prostate cancer samples, and 18 normal prostate tissues, finding that its quantity was significantly decreased in high-graded compared to low-grade prostate cancer and normal prostate tissues. CircFoxo3 inhibited prostate cancer cell survival, migration, invasion and chemoresistance to docetaxel, which was related to circFoxo3's repression of Foxo3 and EMT. Silencing circFoxo3 expression promoted prostate cancer cell survival, migration, invasion and chemoresistance to docetaxel, as well as the positive effects of androgen on prostate cancer viability. Delivery of circfoxo3 enhanced chemosensitivity to docetaxel of prostate tumor-bearing mice and prolonged the life span of mice, while reduction with siRNAs promoted chemoresistance to docetaxel and shorted the life span of the tumor-bearing mice. Targeting circFoxo3/Foxo3/EMT may provide an applicable strategy for exploring potential prognostic and therapeutic approaches for prostate cancer.
引用
收藏
页码：88 / 101
页数：14
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