Possible induction of mania and hypomania by olanzapine or risperidone: A critical review of reported cases

被引：73

作者：

Aubry, JM ^{[1
]}

Simon, AE ^{[1
]}

Bertschy, G ^{[1
]}

机构：

[1] Clin Psychiat Adulte 2, Dept Psychiat, CH-1225 Geneva, Switzerland

来源：

JOURNAL OF CLINICAL PSYCHIATRY | 2000年 / 61卷 / 09期

关键词：

D O I：

10.4088/JCP.v61n0910

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background: Risperidone and olanzapine are atypical antipsychotics that are now widely used in clinical practice. Method: A MEDLINE search (1966-1999) showed that, following the introduction of these agents in recent years, 26 cases of induced hypomanic and manic syndromes have been reported during standard olanzapine (N = 10) or risperidone (N = 16) treatment. Results: A critical analysis of these case reports reveals that the effects on mood were sometimes insufficiently documented and that in about half of them (N = 16) evidence is highly suggestive of a causative role of risperidone or olanzapine in the induction of (hypo)manic symptomatology. Conclusion: Despite limitations, the available literature confirms intriguing effects of these 2 antipsychotics on mood. The risk factors as well as the mechanisms of action underlying these effects remain to be clarified.

引用

页码：649 / 655

页数：7

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